Relative contributions of CA3 and medial entorhinal cortex to memory in rats.
Relative contributions of CA3 and medial entorhinal cortex to memory in rats.
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DOI：
10.3389/fnbeh.2014.00292
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发表时间：
2014
影响因子：
3
通讯作者：
Ferbinteanu J
中科院分区：
文献类型：
--
作者：
O'Reilly KC;Alarcon JM;Ferbinteanu J
海马CA 1区处理空间信息，但海马内与海马外输入CA 1区的空间行为的相对重要性尚不清楚。为了表征这两个来源的输入，起源于海马区CA 3和内侧内嗅皮层（MEC）的相对作用，我们研究了离散的神经毒性病变的CA 3或MEC并发的空间和非空间导航任务的影响，并在传入CA 1的突触传递。在CA 3或MEC区域的病变，废除CA 3-CA 1，或减少MEC-CA 1突触传递，分别损害空间导航和意外干扰线索反应，这表明在某些条件下的训练方案，海马活动可能会影响行为，否则支持非海马神经网络。MEC损伤具有较轻和暂时的行为影响，但也显著放大了CA 3-CA 1通路的传递。广泛的行为训练对CA 3-CA 1传播有类似的，但更温和的影响。因此，皮质输入海马调制CA 1活动直接和间接，通过异突触相互作用，控制信息流在海马回。海马皮质输入受损后，参与正常学习的单独海马内和海马外输入与CA 1的功能耦合可能启动支持行为功能恢复的过程。这样一个过程可以解释如何CA 3病变，这并没有显着修改CA 1神经活动的基本特征，但损害空间回忆，而病变的EC输入CA 1，这降低了空间选择性CA 1发射觅食大鼠，只有轻微的影响空间导航。
The hippocampal CA1 field processes spatial information, but the relative importance of intra- vs. extra-hippocampal sources of input into CA1 for spatial behavior is unclear. To characterize the relative roles of these two sources of input, originating in the hippocampal field CA3 and in the medial entorhinal cortex (MEC), we studied effects of discrete neurotoxic lesions of CA3 or MEC on concurrent spatial and nonspatial navigation tasks, and on synaptic transmission in afferents to CA1. Lesions in CA3 or MEC regions that abolished CA3-CA1, or reduced MEC-CA1 synaptic transmission, respectively, impaired spatial navigation and unexpectedly interfered with cue response, suggesting that in certain conditions of training regimen, hippocampal activity may influence behavior otherwise supported by nonhippocampal neural networks. MEC lesions had milder and temporary behavioral effects, but also markedly amplified transmission in the CA3-CA1 pathway. Extensive behavioral training had a similar, but more modest effect on CA3-CA1 transmission. Thus, cortical input to the hippocampus modulates CA1 activity both directly and indirectly, through heterosynaptic interaction, to control information flow in the hippocampal loop. Following damage to hippocampal cortical input, the functional coupling of separate intra- and extra-hippocampal inputs to CA1 involved in normal learning may initiate processes that support recovery of behavioral function. Such a process may explain how CA3 lesions, which do not significantly modify the basic features of CA1 neural activity, nonetheless impair spatial recall, whereas lesions of EC input to CA1, which reduce the spatial selectivity of CA1 firing in foraging rats, have only mild effects on spatial navigation.
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影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
影响因子：
56.9
作者：
Brun, VH;Otnæss, MK;Moser, EI
通讯作者：
Moser, EI
影响因子：
2.5
作者：
Frank, LM;Brown, EN;Wilson, MA
通讯作者：
Wilson, MA
影响因子：
25
作者：
Boccara, Charlotte N.;Sargolini, Francesca;Moser, May-Britt
通讯作者：
Moser, May-Britt
DOI：
10.1073/pnas.0915059107
发表时间：
2010-02-09
影响因子：
11.1
作者：
Clarke, Julia Rosauro;Cammarota, Martin;Delgado-Garcia, Jose Maria
通讯作者：
Delgado-Garcia, Jose Maria