Pattern separation and pattern completion in Alzheimer's disease: evidence of rapid forgetting in amnestic mild cognitive impairment.
Pattern separation and pattern completion in Alzheimer's disease: evidence of rapid forgetting in amnestic mild cognitive impairment.
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阿尔茨海默氏病的模式分离和模式的完成：快速忘记了柔和的轻度认知障碍的证据。
DOI：
10.1002/hipo.22162
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发表时间：
2013-12
期刊：
影响因子：
3.5
通讯作者：
Molitor, Robert J.
中科院分区：
文献类型：
--
作者：
Ally, Brandon A.;Hussey, Erin P.;Ko, Philip C.;Molitor, Robert J.
在过去的四十年里，与阿尔茨海默病（AD）相关的记忆丧失的特征一直受到广泛的争论。最近的迭代集中在无序编码与快速遗忘。为了解决这个问题，我们使用了行为模式分离任务来评估遗忘型轻度认知功能障碍（aMCI）和轻度AD患者的海马体创建和维持不同的正交视觉记忆表征的能力。我们专门使用了一种基于滞后的连续识别范式来确定aMCI和轻度AD患者是否无法编码视觉记忆表征，或者这些患者是否正确编码了快速遗忘的表征。与AD的快速遗忘假说一致，我们发现aMCI患者的模式分离率随着干扰对象的滞后增加而降低。相比之下，AD患者在三个越来越长的滞后中表现出一贯的模式分离率差。我们提出了一个连续体，反映了潜在的海马神经病理学，即aMCI患者能够正确地编码信息到记忆中，但迅速失去这些记忆表示，和AD患者，谁有广泛的海马和海马旁损伤，不能正确地编码信息在不同的，正交的表示。我们的研究结果还显示，虽然aMCI患者表现出与健康老年人相似的行为模式完成率，但当我们校正反应偏差时，AD患者的模式完成率较低。最后，这些行为模式分离和模式完成的结果进行了讨论的双重过程模型的再认记忆。
Over the past four decades, the characterization of memory loss associated with Alzheimer's disease (AD) has been extensively debated. Recent iterations have focused on disordered encoding versus rapid forgetting. To address this issue, we used a behavioral pattern separation task to assess the ability of the hippocampus to create and maintain distinct and orthogonalized visual memory representations in patients with amnestic mild cognitive impairment (aMCI) and mild AD. We specifically used a lag-based continuous recognition paradigm to determine whether patients with aMCI and mild AD fail to encode visual memory representations or whether these patients properly encode representations that are rapidly forgotten. Consistent with the rapid forgetting hypothesis of AD, we found that patients with aMCI demonstrated decreasing pattern separation rates as the lag of interfering objects increased. In contrast, patients with AD demonstrated consistently poor pattern separation rates across three increasingly longer lags. We propose a continuum that reflects underlying hippocampal neuropathology whereby patients with aMCI are able to properly encode information into memory but rapidly lose these memory representations, and patients with AD, who have extensive hippocampal and parahippocampal damage, cannot properly encode information in distinct, orthogonal representations. Our results also revealed that whereas patients with aMCI demonstrated similar behavioral pattern completion rates to healthy older adults, patients with AD showed lower pattern completion rates when we corrected for response bias. Finally, these behavioral pattern separation and pattern completion results are discussed in terms of the dual process model of recognition memory.
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影响因子：
2.6
作者：
Embree LM;Budson AE;Ally BA
通讯作者：
Ally BA
影响因子：
3.6
作者：
BECKER, JT;BOLLER, F;MCGONIGLEGIBSON, KL
通讯作者：
MCGONIGLEGIBSON, KL
影响因子：
1.4
作者：
Budson, Andrew E.;Michalska, Kalina J.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
2.2
作者：
CARLESIMO, GA;FADDA, L;CALTAGIRONE, C
通讯作者：
CALTAGIRONE, C
影响因子：
2.4
作者：
Deason, Rebecca G.;Hussey, Erin P.;Ally, Brandon A.
通讯作者：
Ally, Brandon A.