Alterations in amygdala functional connectivity reflect early temperament.
Alterations in amygdala functional connectivity reflect early temperament.
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杏仁核功能连通性的改变反映了早期气质。
DOI：
10.1016/j.biopsycho.2014.09.007
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发表时间：
2014-12
影响因子：
2.6
通讯作者：
Ernst, Monique
中科院分区：
文献类型：
--
作者：
Roy, Amy Krain;Benson, Brenda E.;Degnan, Kathryn A.;Perez-Edgar, Koraly;Pine, Daniel S.;Fox, Nathan A.;Ernst, Monique
行为抑制（BI）是一种在生命早期发现的气质，与焦虑症的风险增加有关。杏仁核高反应性，发现在行为抑制和焦虑的个人，表明杏仁核功能障碍可能是焦虑风险的标志。然而，更广泛的杏仁核网络尚未在有儿童BI病史的个体中进行检查。本研究采用静息态fMRI评估杏仁核内在功能连接（iFC）在38名健康的年轻人（19与BI的历史，19没有历史的BI）从纵向研究中选择。比较各组之间的中央内侧、基底外侧和浅杏仁核iFC，并检查其与焦虑的自我报告测量的关系。杏仁核iFC与前额叶皮质、纹状体、前额叶和小脑存在组间差异。在进入扫描仪之前，以儿童BI为特征的成年人赞同更大的状态焦虑，这与几个组的差异有关。研究结果支持持久的影响，BI对杏仁核电路，即使在没有目前的精神病理学。
Behavioral inhibition (BI) is a temperament identified early in life that is associated with increased risk for anxiety disorders. Amygdala hyperresponsivity, found both in behaviorally inhibited and anxious individuals, suggests that amygdala dysfunction may represent a marker of anxiety risk. However, broader amygdala networks have not been examined in individuals with a history of childhood BI. This study uses resting state fMRI to assess amygdala intrinsic functional connectivity (iFC) in 38 healthy young adults (19 with a history of BI, 19 with no history of BI) selected from a longitudinal study. Centromedial, basolateral, and superficial amygdala iFCs were compared between groups and examined in relation to self-report measures of anxiety. Group differences were observed in amygdala iFC with prefrontal cortex, striatum, anterior insula, and cerebellum. Adults characterized with BI in childhood endorsed greater state anxiety prior to entering the scanner, which was associated with several of the group differences. Findings support enduring effects of BI on amygdala circuitry, even in the absence of current psychopathology.
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影响因子：
2.6
作者：
Helfinstein, Sarah M.;Benson, Brenda;Ernst, Monique
通讯作者：
Ernst, Monique
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
DOI：
10.3109/10253890.2011.578184
发表时间：
2012-01
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Myers CE;Vanmeenen KM;McAuley JD;Beck KD;Pang KC;Servatius RJ
通讯作者：
Servatius RJ
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
影响因子：
2.3
作者：
Hoehn-Saric, R;Schlund, MW;Wong, SHY
通讯作者：
Wong, SHY