A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.
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DOI：
10.1126/science.1181886
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发表时间：
2010-02-12
期刊：
影响因子：
--
通讯作者：
Casey BJ
中科院分区：
文献类型：
--
作者：
Soliman F;Glatt CE;Bath KG;Levita L;Jones RM;Pattwell SS;Jing D;Tottenham N;Amso D;Somerville LH;Voss HU;Glover G;Ballon DJ;Liston C;Teslovich T;Van Kempen T;Lee FS;Casey BJ
老鼠模型对研究与行为有关的基因很有用，但它们是否与人类行为相关尚不清楚。在这里，我们在小鼠和人类中发现了由脑源性神经营养因子(BDNF)基因常见的单核苷酸多态性导致的平行表型，该基因与焦虑相关的行为有关。表达变异型BDNF的近交系基因敲入小鼠品系概括了人类多态的表型效应。这两个人在消除条件性恐惧反应方面都受到了损害，而这一反应与人类非典型的额叶杏仁核活动相平行。因此，这种变异的BDNF等位基因可能在焦虑症中发挥作用，表现出对发出安全与威胁信号的线索的学习障碍，以及依赖于消退机制的治疗的有效性，如暴露疗法。
Mouse models are useful for studying genes involved in behavior, but whether they are relevant for human behavior is unclear. Here, we identified parallel phenotypes in mice and humans resulting from a common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, which is involved in anxiety-related behavior. An inbred genetic knock-in mouse strain expressing the variant BDNF recapitulated the phenotypic effects of the human polymorphism. Both were impaired in extinguishing a conditioned fear response, which was paralleled by atypical frontoamygdala activity in humans. Thus, this variant BDNF allele may play a role in anxiety disorders showing impaired learning of cues that signal safety versus threat, and in the efficacy of treatments that rely on extinction mechanisms such as exposure therapy.
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DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
16.2
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
1.9
作者：
KIM, M;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
10.6
作者：
Liberzon, I;Taylor, SF;Fig, LM
通讯作者：
Fig, LM
影响因子：
1.9
作者：
Nader, K;LeDoux, J
通讯作者：
LeDoux, J