Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions.
Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions.
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DOI：
10.1016/j.dental.2018.09.013
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Finer Y
中科院分区：
文献类型：
--
作者：
Stewart CA;Finer Y
尽管经过几十年的发展和作为牙医首选修复材料的地位，树脂复合修复剂和粘结剂显示出许多缺点，限制了它们在口腔中的长期存活。在这里，我们回顾过去和目前的工作，以了解这些挑战和方法，以改进牙科材料和延长修复服务寿命。总结和分析了一些研究人员和我们自己的同行评议工作。我们还包括我们自己尚未发表的作品。对牙科材料的挑战，评估新材料的方法，以及最近的材料改进和研究方向进行了介绍。机械应力，宿主和细菌的生物降解，以及继发性龋病的形成都是导致修复失败的原因。特别是，几种宿主和细菌衍生的酶降解杂合层的树脂和胶原成分，扩大了边缘缺口，增加了接触细菌和唾液的机会。此外，树脂生物降解副产物上调了致龋菌的毒力，创造了一个增加生物降解率的正反馈循环。这些因素协同作用，降低修复边缘，导致继发性龋病和修复失败。在生产耐生物降解的水解性稳定树脂以及减少修复周围细菌负荷的抗菌材料方面取得了重大进展。理想情况下，这两种方法应该结合在一起，以一种整体的方法进行修复保护。口腔是一个复杂的环境，对长期的材料成功提出了一系列挑战；材料测试条件应该是全面的，并密切模拟病原性口腔条件。
Despite decades of development and their status as the restorative material of choice for dentists, resin composite restoratives and adhesives exhibit a number of shortcomings that limit their long-term survival in the oral cavity. Herein we review past and current work to understand these challenges and approaches to improve dental materials and extend restoration service life. Peer-reviewed work from a number of researchers as well as our own are summarized and analyzed. We also include yet-unpublished work of our own. Challenges to dental materials, methods to assess new materials, and recent material improvements and research directions are presented. Mechanical stress, host- and bacterial- biodegradation, and secondary caries formation all contribute to restoration failure. In particular, several host- and bacterial-derived enzymes degrade the resin and collagen components of the hybrid layer, expanding the marginal gap and increasing access to bacteria and saliva. Furthermore, the virulence of cariogenic bacteria is up-regulated by resin biodegradation by-products, creating a positive feedback loop that increases biodegradation. These factors work synergistically to degrade the restoration margin, leading to secondary caries and restoration failure. Significant progress has been made to produce hydrolytically stable resins to resist biodegradation, as well as antimicrobial materials to reduce bacterial load around the restoration. Ideally, these two approaches should be combined in a holistic approach to restoration preservation. The oral cavity is a complex environment that poses an array of challenges to long-term material success; materials testing conditions should be comprehensive and closely mimic pathogenic oral conditions.
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影响因子：
7.6
作者：
Carrilho, M. R. O.;Carvalho, R. M.;Tjaderhane, L.
通讯作者：
Tjaderhane, L.
DOI：
10.1073/pnas.1010341107
发表时间：
2010-12-21
影响因子：
11.1
作者：
Beyth, Nurit;Yudovin-Farber, Ira;Weiss, Ervin I.
通讯作者：
Weiss, Ervin I.
影响因子：
5
作者：
Delaviz, Yasaman;Nascimento, Mitchell A.;Santerre, J. Paul
通讯作者：
Santerre, J. Paul
DOI：
10.14219/jada.archive.1961.0215
发表时间：
1961-01-01
影响因子：
3.9
作者：
CHAUNCEY, HH
通讯作者：
CHAUNCEY, HH
影响因子：
7.6
作者：
Carrilho, M. R. O.;Geraldeli, S.;Pashley, D.
通讯作者：
Pashley, D.