Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults.
Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults.
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DOI：
10.3390/jcm11206172
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发表时间：
2022-10-19
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
众所周知，骨骼和肌肉质量的减少是同时发生的。α-肌动蛋白3(ACTN3)基因已被证明可能影响骨骼和肌肉质量。在这项研究中，我们调查了ACTN3型与60岁≥社区成年人骨和肌肉质量丢失的关系。这项研究对参加社区健康检查的295名参与者的数据进行了横断面分析。ACTN3基因分型为RR、RX和XX三种类型。骨量损失定义为跟骨声速T-分值分别为−1.32和−1.37，肌肉质量损失定义为男性和女性附件骨骼肌指数分别为7.0 kg/m2和5.7 kg/m2。骨和肌肉联合消失组中XX、RX和RR的比例分别为33.8%、30.8%和16.7%，XX有明显升高的趋势。多项Logistic回归分析显示，与RR组(协变量：年龄、性别、握力和药物)相比，XX进入骨骼和肌肉联合减重组的优势比为3.00(95%可信区间为1.05-8.54)。XX的ACTN3基因与骨骼和肌肉的共病丢失率较高相关。因此，应考虑ACTN3基因分型，以防止骨和肌肉的混合性丢失。
Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05–8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.
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影响因子：
4
作者：
He, H.;Liu, Y.;Deng, H. -W.
通讯作者：
Deng, H. -W.
影响因子：
4
作者：
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Martini, Ligia A.
影响因子：
5.6
作者：
Curtis E;Litwic A;Cooper C;Dennison E
通讯作者：
Dennison E
影响因子：
4
作者：
Di Monaco, Marco;Vallero, Fulvia;Tappero, Rosa
通讯作者：
Tappero, Rosa
影响因子：
--
作者：
Cariati I;Bonanni R;Onorato F;Mastrogregori A;Rossi D;Iundusi R;Gasbarra E;Tancredi V;Tarantino U
通讯作者：
Tarantino U