Pancreatitis and pancreatic cancer in two large pooled case-control studies.
Pancreatitis and pancreatic cancer in two large pooled case-control studies.
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DOI：
10.1007/s10552-009-9424-x
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发表时间：
2009-11
影响因子：
2.3
通讯作者：
Holly, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Bracci, Paige M.;Wang, Furong;Hassan, Manal M.;Gupta, Samir;Li, Donghui;Holly, Elizabeth A.
在大规模人群研究中，胰腺炎病程与胰腺癌之间的关系尚未得到很好的描述。我们进行了详细的分析，以确定胰腺炎发作和胰腺癌风险之间的关系。数据来自两项胰腺癌病例对照研究（n = 4515），分别在旧金山弗朗西斯科湾地区和医学博士。收集安德森癌症中心的1，663例病例和2，852例频率匹配的对照进行分析。调整后的比值比（OR）采用随机效应模型进行估计。在汇总多变量模型中，胰腺炎病史与胰腺癌风险估计值增加7.2倍相关[95%置信区间（CI）：4.0，13]。在年龄<55岁的参与者中，风险估计值接近10倍（OR = 9.9，95%CI：3.5，28）。较短的胰腺炎病史与胰腺癌的关系比较长的胰腺炎病史更密切：<3年（OR = 29，95% CI：12，71），3 - 10年（OR = 2.6，95% CI：1.5，5.6）和> 10年（OR = 1.8，95% CI：0.7，4.5，p趋势<0.001）。短期胰腺炎病史与胰腺癌高度相关，表明胰腺炎可能是某些个体胰腺癌的早期表现。胰腺癌应考虑在个人与胰腺炎发作的鉴别诊断。
The association between duration of pancreatitis and pancreatic cancer has not been well characterized in large population-based studies. We conducted detailed analyses to determine the association between pancreatitis onset and pancreatic cancer risk. Data from two case–control studies of pancreatic cancer (n = 4515) in the San Francisco Bay Area and the M.D. Anderson Cancer Center were pooled for analysis (1,663 cases, 2,852 frequency-matched controls). Adjusted odds ratios (OR) were estimated using a random-effects model. In the pooled multivariable model, history of pancreatitis was associated with a 7.2-fold increased risk estimate for pancreatic cancer [95% confidence interval (CI): 4.0, 13]. The risk estimate was nearly 10-fold in participants aged <55 years (OR = 9.9, 95% CI: 3.5, 28). A shorter temporal history of pancreatitis was more closely associated with pancreatic cancer than was a longer temporal history: <3 years (OR = 29, 95% CI: 12, 71), 3–10 years (OR = 2.6, 95% CI: 1.5, 5.6), and >10 years (OR = 1.8, 95% CI: 0.7, 4.5, p trend < 0.001). A short temporal history of pancreatitis was highly associated with pancreatic cancer, suggesting that pancreatitis may be an early manifestation of pancreatic cancer in some individuals. Pancreatic cancer should be considered in the differential diagnosis of individuals with an episode of pancreatitis.
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影响因子：
4.5
作者：
Frulloni, L.;Gabbrielli, A.;Cavallini, G.
通讯作者：
Cavallini, G.
影响因子：
2.9
作者：
Gullo, L;Migliori, M;Beger, H
通讯作者：
Beger, H
影响因子：
9.6
作者：
Appelros, S;Borgström, A
通讯作者：
Borgström, A
影响因子：
6.4
作者：
FARROW, DC;DAVIS, S
通讯作者：
DAVIS, S
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N