Neural Responses to Peer Rejection in Anxious Adolescents: Contributions from the Amygdala-Hippocampal Complex.
Neural Responses to Peer Rejection in Anxious Adolescents: Contributions from the Amygdala-Hippocampal Complex.
复制标题
DOI：
10.1177/0165025411406854
复制
发表时间：
2012-01
影响因子：
3.7
通讯作者：
Nelson EE
中科院分区：
文献类型：
--
作者：
Lau JYF;Guyer AE;Tone EB;Jenness J;Parrish JM;Pine DS;Nelson EE
同伴拒绝有力地预测了青少年的焦虑。虽然认知差异会影响对社会反馈的焦虑反应，但对神经的贡献知之甚少。12名焦虑和12名年龄、性别和智商匹配的精神健康青少年在神经成像扫描仪中执行聊天室任务时，收到了来自未知同龄人的“不感兴趣”和“感兴趣”的反馈。没有组的差异出现在主观评级同行反馈，但所有的参与者报告更多的负面情绪被拒绝（比接受）的同行，他们分配了高的可取性评级。进一步强调这种反馈的显着性，所有青少年，独立的焦虑水平，表现出升高的反应，在杏仁核-海马复合体双边，在预期的反馈。然而，焦虑的青少年与健康的青少年在排斥反应后持续的杏仁核-海马激活模式不同。这些数据对使用神经影像学数据为社交焦虑的心理治疗方法提供信息具有有趣的意义。
Peer rejection powerfully predicts adolescent anxiety. While cognitive differences influence anxious responses to social feedback, little is known about neural contributions. Twelve anxious and 12 age-, gender- and IQ-matched, psychiatrically-healthy adolescents received ‘not interested’ and ‘interested’ feedback from unknown peers during a Chatroom task administered in a neuroimaging scanner. No group differences emerged in subjective ratings to peer feedback, but all participants reported more negative emotion at being rejected (than accepted) by peers to whom they had assigned high desirability ratings. Further highlighting the salience of such feedback, all adolescents, independent of anxiety levels, manifested elevated responses in the amygdala-hippocampal complex bilaterally, during the anticipation of feedback. However, anxious adolescents differed from healthy adolescents in their patterns of persistent amygdala-hippocampal activation following rejection. These data carry interesting implications for using neuroimaging data to inform psychotherapeutic approaches to social anxiety.
登录
查看更多内容
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
17.7
作者：
Monk, Christopher S.;Nelson, Eric E.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.