On the Integration of Space, Time, and Memory.

On the Integration of Space, Time, and Memory.
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DOI:
10.1016/j.neuron.2017.06.036
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发表时间:
2017-08-30
期刊:
影响因子:
16.2
通讯作者:
Eichenbaum H
Eichenbaum H
中科院分区:
医学1区
文献类型:
--
作者:
Eichenbaum H

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海马体以映射空间组织环境中的位置而闻名,最近的几项研究表明,海马体网络也映射时间组织体验中的时刻。在这里,我考虑的是空间和时间是如何在记忆的表现中整合的。空间和时间认知的大脑通路涉及汇聚在海马区的重叠和相互作用的系统。有证据表明,记忆的空间和时间方面在海马亚区的电路中的处理略有不同,但作为空间和时间的独立、多路表示,完全整合在CA1神经元网络中。海马体网络还映射了事件之间广泛的抽象关系的记忆,这表明关于空间和时间组织的发现反映了一种组织记忆的普遍机制。
The hippocampus is famous for mapping locations in spatially organized environments and several recent studies have shown that hippocampal networks also map moments in temporally organized experiences. Here I consider how space and time are integrated in the representation of memories. The brain pathways for spatial and temporal cognition involve overlapping and interacting systems that converge on the hippocampal region. There is evidence that spatial and temporal aspects of memory are processed somewhat differently in the circuitry of hippocampal subregions but become fully integrated within CA1 neuronal networks as independent, multiplexed representations of space and time. Hippocampal networks also map memories across a broad range of abstract relations among events, suggesting that the findings on spatial and temporal organization reflect a generalized mechanism for organizing memories.
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