A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia.
A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia.
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DOI：
10.1016/j.pscychresns.2010.08.004
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发表时间：
2010-12-30
影响因子：
2.3
通讯作者：
Shenton, Martha E.
中科院分区：
文献类型：
--
作者：
Levitt, James J.;Kubicki, Marek;Nestor, Paul G.;Ersner-Hershfield, Hal;Westin, C-F;Alvarado, Jorge L.;Kikinis, Ron;Jolesz, Ferenc A.;McCarley, Robert W.;Shenton, Martha E.
关键词：
额叶皮层下认知和边缘反馈回路调节高级认知功能。这些反馈回路的最后一步是通过内囊前肢的丘脑-皮质投射（AL-IC）。利用扩散张量成像（DTI），我们评估异常的AL IC纤维束精神分裂症。16名慢性精神分裂症患者和19名男性正常对照组，在1.5Tesla GE系统上进行DTI。我们测量了扩散指数、各向异性分数（FA）平均扩散率（MD）、径向扩散率（RD）和轴向扩散率（AD），并根据FA图、AL-IC体积（针对颅内内容物（ICC）进行了标准化）进行手动分割。结果显示，在ICC校正体积的AL-IC，精神分裂症，但没有显示扩散测量组差异的AL-IC FA，MD，RD或AD。此外，结果显示，在精神分裂症患者中，AL-IC FA与空间和口头陈述/情景记忆测量的表现呈正相关，并且右侧AL-IC ICC校正体积与威斯康星州卡片分类测试（WCST）上的更多持续反应呈正相关。我们发现，精神分裂症患者的AL-IC ICC校正体积减少，而FA、MD、RD或AD组无差异，这表明精神分裂症患者的皮质下白色物质区域存在结构异常，该区域包含重要的认知和边缘反馈通路，可调节前额叶皮质功能。尽管没有表现出组间差异FA，我们发现，AL-IC FA是一个很好的预测精神分裂症的空间和口头陈述/情节记忆的表现。
Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal capsule (AL-IC). Using diffusion tensor imaging (DTI), we evaluated abnormalities in the AL-IC fiber tract in schizophrenia. 16 chronic schizophrenics and 19 male, normal controls group matched for handedness, age, and parental SES, underwent DTI on a 1.5 Tesla GE system. We measured the diffusion indices, fractional anisotropy (FA) mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), and manually segmented, based on FA maps, AL-IC volume, normalized for intracranial contents (ICC). Results showed a significant reduction in the ICC corrected volume of the AL-IC, in schizophrenia, but did not show diffusion measure group differences in the AL-IC in FA, MD, RD or AD. In addition, results revealed in schizophrenics, AL-IC FA correlated positively with performance on measures of spatial and verbal declarative/episodic memory, and right AL-IC ICC corrected volume correlated positively with more perseverative responses on the Wisconsin Card Sort Test (WCST). We found a reduction in AL-IC ICC corrected volume in schizophrenia, without FA, MD, RD or AD group differences, implicating the presence of a structural abnormality in schizophrenia in this subcortical white matter region which contains important cognitive, and limbic feedback pathways which modulate prefrontal cortical function. Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia.
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影响因子：
4.8
作者：
Jeong, Bumseok;Wible, Cynthia G.;Hashimoto, Ryu-ichiro;Kubicki, Marek
通讯作者：
Kubicki, Marek
影响因子：
17.7
作者：
Kasai, K;Shenton, ME;McCarley, RW
通讯作者：
McCarley, RW
DOI：
10.1176/appi.neuropsych.18.3.364
发表时间：
2006-06-01
影响因子：
2.9
作者：
Brickman, Adam M.;Buchsbaum, Monte S.;Shihabuddin, Lina
通讯作者：
Shihabuddin, Lina
影响因子：
4.4
作者：
Hof, PR;Haroutunian, V;Buxbaum, JD
通讯作者：
Buxbaum, JD
影响因子：
10.6
作者：
Kubicki, M;Westin, CF;Shenton, ME
通讯作者：
Shenton, ME