Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.
Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.
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DOI：
10.1016/j.jalz.2018.04.009
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Beydoun HA;Elbejjani M;Dore GA;Zonderman AB
感染因子最近被认为与阿尔茨海默病（AD）和其他痴呆症的病因有关，特别是幽门螺杆菌。我们测试了H。在一项回顾性队列研究中，幽门螺杆菌血清阳性与全因痴呆和AD痴呆事件以及AD相关死亡率相关。使用了国家健康和营养调查III第1阶段（1988-1991）和1999-2000年与医疗保险和国家死亡指数登记相关的数据（基线年龄≥45岁，随访至2013年，Npooled = 5927）。H. pylori血清阳性和AD死亡率在男性中发现（风险比adj，合并= 4.33，95%置信区间：1.51-12.41，P =.006），在AD和全因痴呆事件中重复，风险比adj，合并= 1.45（95%置信区间：1.03-2.04，P = .035）和风险比adj，III = 1.44（95%置信区间：1.05-1.98，P = .022）。这些关联在社会经济地位较高的群体中也是积极的。综上所述，H.幽门螺杆菌血清阳性与AD死亡率、全因痴呆和AD痴呆的直接关联仅限于男性和社会经济地位较高的群体。爱思唯尔公司出版代表老年痴呆症协会
Infectious agents were recently implicated in Alzheimer’s disease (AD) and etiology of other dementias, notably Helicobacter pylori. We tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988–1991) and 1999–2000 linked with Medicare and National Death Index registries, were used (baseline age ≥45 y, follow-up to 2013, Npooled = 5927). A positive association between H. pylori seropositivity and AD mortality was found in men (hazard ratioadj, pooled = 4.33, 95% confidence interval: 1.51–12.41, P =.006), which was replicated for incident AD and all-cause dementia, with hazard ratioadj, pooled = 1.45 (95% confidence interval: 1.03–2.04, P = .035) and hazard ratioadj, III = 1.44 (95% confidence interval: 1.05–1.98, P = .022), respectively. These associations were also positive among higher socioeconomic status groups. In sum, H. pylori seropositivity’s direct association with AD mortality, all-cause dementia, and AD dementia was restricted to men and to higher socioeconomic status groups. Published by Elsevier Inc. on behalf of the Alzheimer’s Association.
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