Restoring Good Health in Elderly with Diverse Gut Microbiome and Food Intake Restriction to Combat COVID-19.
Restoring Good Health in Elderly with Diverse Gut Microbiome and Food Intake Restriction to Combat COVID-19.
复制标题
DOI：
10.1007/s12088-020-00913-3
复制
发表时间：
2021-03
影响因子：
3
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Yu L
新冠肺炎仍然是一个持续的全球威胁。患有心血管和肺部疾病、糖尿病、肥胖等潜在健康状况的老年人最容易患上这种疾病。治愈既有的健康状况将极大地提高一个人对新冠肺炎的韧性，降低老年人的死亡率。消化和免疫形成了一个综合的营养获取过程，特别是从活的微生物细胞中获得必需的氨基酸和必需的脂肪酸。成人成熟的强大免疫力加上肠道生物失调是病态肥胖、糖尿病、心血管和肺部疾病等营养失调的主要原因。营养失调反过来又会加剧生物失调。人类微生物群具有内在的二元性。虽然多样化的微生物群为我们的身体提供了全方位的必要营养，但营养障碍加剧了我们身体或体内许多部位的微生物群过度生长(生物失调)，并是这些部位慢性炎症的主要原因。就新冠肺炎而言，营养失调会损害免疫力，导致高度炎症，并导致免疫系统长期过量分泌细胞因子，即细胞因子风暴。限制进食诱导的自噬是微生物区系过度生长的理想抑制因素，因为自噬剥夺了微生物区系复制所需的过量营养。自噬还可以减轻炎症。因此，作为预防措施，作者建议在多元化的肠道微生物群的支持下，以及每日定期限制食物摄入量的支持下，恢复老年人的健康，从而降低即使感染新冠肺炎也发展为重症的风险。
COVID-19 continues to be an ongoing global threat. The elderly with underlying health conditions like cardiovascular and lung diseases, diabetes, obesity, are the most vulnerable to this disease. Curing the pre-existing health conditions will greatly increase a person’s resilience to COVID-19 and lower the death rate of the old people. Digestion and immunity form an integrated nutrition acquisition process, especially in obtaining essential amino acids and essential fatty acids from living microbial cells. A mature strong immunity coupled with gut dysbiosis in adults is the main cause of nutritional disorders like morbid obesity, diabetes mellitus, cardiovascular and pulmonary diseases. Nutrition disorders in return worsen dysbiosis. Human microbiome has an intrinsic duality. While a diverse microbiome provides a full spectrum of essential nutrients to our body, nutrition disorders fuel overgrowth of microbiota (dysbiosis) at many sites on or inside our body, and are the main causes of chronic inflammation at these sites. In the case of COVID-19, nutritional disorder impairs the immunity, causes hyperinflammation, and leads to the protracted overload of cytokines by the immune system, i.e., the cytokine storm. Autophagy induced by restrictive eating is an ideal inhibitor of microbiota overgrowth, as autophagy deprives microbiota of excessive nutrition for replication. Autophagy also attenuates inflammation. Therefore, as a precaution, the author suggests restoring good health in the elderly with the support from a diverse gut microbiome and daily regular food intake restriction, so as to lower the risk of developing into severe case even if they are infected by COVID-19.
登录
查看更多内容
影响因子：
3
作者：
Rishi P;Thakur K;Vij S;Rishi L;Singh A;Kaur IP;Patel SKS;Lee JK;Kalia VC
通讯作者：
Kalia VC
DOI：
10.1097/mco.0b013e32832182ee
发表时间：
2009-03-01
影响因子：
3.1
作者：
Garbarino, Jeanne;Sturley, Stephen L.
通讯作者：
Sturley, Stephen L.
衰老、男性性别、肥胖和代谢性炎症为 COVID-19 创造了完美风暴
影响因子：
7.7
作者：
Mauvais-Jarvis, Franck
通讯作者：
Mauvais-Jarvis, Franck
影响因子：
15.5
作者：
Vandegrift R;Bateman AC;Siemens KN;Nguyen M;Wilson HE;Green JL;Van Den Wymelenberg KG;Hickey RJ
通讯作者：
Hickey RJ
影响因子：
8.7
作者：
Alexander KL;Targan SR;Elson CO 3rd
通讯作者：
Elson CO 3rd