Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.
Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.
复制标题
DOI：
10.1016/j.physbeh.2021.113557
复制
发表时间：
2021-10-15
影响因子：
2.9
通讯作者：
Cassaday HJ
中科院分区：
文献类型：
--
作者：
Waite L;Bonardi C;Stevenson CW;Cassaday HJ
白化病Wistar和着色Lister Hooded大鼠的行为比较。受试者内抑制性学习（A +/AX-）和新的物体识别变体。Wistars比Lister Hooded大鼠表现出更明显的抑制性辨别。新的物体识别歧视的一致性表现出应变差异。Wistars适用于联想学习和基本的物体识别过程。视觉能力和探索倾向的应变差异可以混淆大鼠在学习和记忆的认知测试中的表现。在本研究中，我们比较了白化病Wistar和着色Lister Hooded大鼠在食欲条件反射和识别记忆过程中的表现，特别是受试者内抑制性学习（A+ /AX-）和新物体识别（NOR）变体。抑制任务包括兴奋性训练阶段、总结和延迟测试。差异评分用于帮助控制基线鼻戳反应的个体差异。在10分钟延迟后、24小时延迟后并使用近因变量测试NOR。辨别率用于控制探索性活动的个体差异。在抑制性学习过程中，Lister Hooded表现出更多的杂志活动之前，刺激介绍比Wistar大鼠，但这是一个短暂的影响，仅限于第1天的兴奋性训练。在兴奋性训练阶段，大鼠的联想学习能力不存在应变差异。Wistars继续在抑制性辨别阶段显示出一些性能优势，并且稍微更强的阻滞测试性能。在NOR任务中，应变对认知性能没有显著影响，但Wistars在10分钟延迟变量中表现出一定的优势，而在24小时延迟和相对近度NOR变量中，Lister Hooded大鼠表现出一定的优势。总体而言，本研究的结果证实了Wistar大鼠适用于联想学习和基本NOR程序。
Behavioural comparisons of albino Wistar and pigmented Lister Hooded rats. Within-subjects inhibitory learning (A +/AX-) and novel object recognition variants. Wistars showed clearer inhibitory discrimination than Lister Hooded rats. Novel object recognition discriminations showed strain differences in consistency. Wistars are good for associative learning and basic object recognition procedures. Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetitive conditioning and recognition memory procedures, specifically within-subjects inhibitory learning (A+ /AX-) and novel object recognition (NOR) variants. The inhibition task included an excitatory training stage and summation and retardation tests. Difference scores were used to help control for individual variation in baseline nosepoke responding. NOR was tested after a 10 min delay, following 24hr delay and using a recency variant. Discrimination ratios were used to control for individual variation in exploratory activity. In the inhibitory learning procedure, Lister Hooded showed more magazine activity prior to stimulus presentations than Wistar rats but this was a transient effect restricted to day 1 of excitatory training. There was no strain difference in associative learning at the excitatory training stage. The Wistars went on to show some performance advantage at the inhibitory discrimination stage and marginally stronger retardation test performance. In the NOR tasks, there was no significant effect of strain on cognitive performance, but the Wistars showed some advantage in the 10 min delay variant, whereas in the 24hr delay and relative recency NOR variants, the Lister Hooded rats showed some advantage. Overall the results of the present study confirm the suitability of Wistar rats for use in associative learning and basic NOR procedures.
登录
查看更多内容
DOI：
10.1016/j.euroneuro.2015.07.018
发表时间：
2015-11
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
--
作者：
Pezze MA;Marshall HJ;Fone KC;Cassaday HJ
通讯作者：
Cassaday HJ
影响因子：
0.8
作者：
CLAUSE, BT
通讯作者：
CLAUSE, BT
影响因子：
2.7
作者：
Migo, EA;Corbett, K;Cassaday, HJ
通讯作者：
Cassaday, HJ
影响因子：
2.7
作者：
Mitchell, JB;Laiacona, J
通讯作者：
Laiacona, J
影响因子：
1.9
作者：
Nelson, Andrew J. D.;Cooper, Molly T.;Cassaday, Helen J.
通讯作者：
Cassaday, Helen J.