Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.
Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.
复制标题
DOI：
10.1016/j.pharmthera.2008.07.006
复制
发表时间：
2008-11
影响因子：
13.5
通讯作者：
Covington HE 3rd
中科院分区：
文献类型：
--
作者：
Miczek KA;Yap JJ;Covington HE 3rd
表面上令人厌恶的社会压力对引发、放大和延长对吸毒的强烈奖励的影响，是一个需要解决的明显矛盾。社会压力包括各种类型的重大生活事件，从母亲分离压力，青春期和成年期短暂的社会对抗，到持续的从属压力，每一种都有自己的行为和生理特征。由VTA-伏隔核-PFC-杏仁核组成的神经回路被短暂的社会应激激活，这对DA介导的行为敏感化和刺激剂消耗的增加至关重要。由中缝-PFC-海马区组成的第二个神经回路被持续从属压力和其他类型的不可控压力激活。就治疗学的发展而言，短暂的母体分离应激已被证明有助于表征作用于具有抗焦虑潜力的GABA、谷氨酸、5-羟色胺和阿片受体亚型的化合物。虽然在啮齿动物生命的头两周，在经历了长时间的母体分离后，成年期间酒精和可卡因的摄入量大幅增加，但这些影响可能会受到其他尚不确定的因素的调节。短暂的失败应激可以产生行为敏感化，这与兴奋剂和阿片类药物自我给药的升级和持续时间有关，而持续的从属应激会导致快感丧失样的效应。了解婴儿期和成年期从间歇性社交压力向持续性社交压力转变的细胞内级联事件，可能有助于洞察对成瘾和情感障碍至关重要的基本奖励过程的调节。
The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stress encompasses various types of significant life events ranging from maternal separation stress, brief episodes of social confrontations in adolescence and adulthood, to continuous subordination stress, each with its own behavioral and physiological profile. The neural circuit comprising the VTA–accumbens–PFC–amygdala is activated by brief episodes of social stress, which is critical for the DA-mediated behavioral sensitization and increased stimulant consumption. A second neural circuit comprising the raphe–PFC–hippocampus is activated by continuous subordination stress and other types of uncontrollable stress. In terms of the development of therapeutics, brief maternal separation stress has proven useful in characterizing compounds acting on subtypes of GABA, glutamate, serotonin and opioid receptors with anxiolytic potential. While large increases in alcohol and cocaine intake during adulthood have been seen after prolonged maternal separation experiences during the first two weeks of rodent life, these effects may be modulated by additional yet to be identified factors. Brief episodes of defeat stress can engender behavioral sensitization that is relevant to escalated and prolonged self-administration of stimulants and possibly opioids, whereas continuous subordination stress leads to anhedonia-like effects. Understanding the intracellular cascade of events for the transition from episodic to continuous social stress in infancy and adulthood may provide insight into the modulation of basic reward processes that are critical for addictive and affective disorders.
登录
查看更多内容
影响因子：
56.9
作者：
BEER, B;CHASIN, M;HOROVITZ, ZP
通讯作者：
HOROVITZ, ZP
影响因子：
3.6
作者：
BARDO, MT;BOWLING, SL;DWOSKIN, LP
通讯作者：
DWOSKIN, LP
DOI：
10.1037/h0029162
发表时间：
1970-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BAENNING.LP
通讯作者：
BAENNING.LP
影响因子：
3
作者：
ALTSTEIN, M;WHITNALL, MH;GAINER, H
通讯作者：
GAINER, H
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL