Prevalence of AD among whites
Prevalence of AD among whites
复制标题
白人中AD的患病率
作者：
L. Hy;D. Keller
目的：使用四种基于严重程度的定义中的每一种来确定白人特定年龄和性别的AD患病率：被诊断为至少患有可疑AD的人，被诊断为至少患有轻度AD的人，被诊断为中度或重度AD的人，以及被诊断为重度AD的人。方法：收集21项针对欧洲人和北美人的研究数据。结果：从经验来看，来自东波士顿的一项研究是一个异常值。应用于1996年的美国人口，获得的估计得出的流行率为170万至190万例，这取决于离群值研究是否被排除或包括在内。结论：考虑到疾病的严重性，白人人群对AD患病率的估计比通常承认的更一致。通过将疾病严重性包括在病例定义中，报告率的差异大大减少。东波士顿研究的离群点地位似乎是由于使用了与其他20项研究不同的AD定义。讨论了这些估计数与400万个病例的一般估计数之间的差异的其他解释。
Objective: To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. Methods: Data from 21 studies of Europeans and North Americans were pooled. Results: Empirically, one study, from East Boston, is an outlier. Applied to the US population of 1996, the obtained estimates yield a prevalence of 1.7 to 1.9 million cases, depending on whether the outlier study is excluded or included. Conclusions: With disease severity taken into account, estimates of AD prevalence from white populations are more consistent than is usually acknowledged. By including disease severity in the case definition, variations in reported rates are much reduced. The outlier status of the East Boston study appears to result from the use of a definition of AD that differs from that used in the other 20 studies. Alternative explanations of the discrepancy between these estimates and the common estimate of 4 million cases are discussed.
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影响因子：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
通讯作者：
Hall, KS
DOI：
10.1001/jama.1989.03430180093036
发表时间：
1989-11-10
影响因子：
120.7
作者：
EVANS, DA;FUNKENSTEIN, H;TAYLOR, JO
通讯作者：
TAYLOR, JO
老年社区阿尔茨海默病的患病率。
影响因子：
5
作者：
Pfeffer,RI;Afifi,AA;Chance,JM
通讯作者：
Chance,JM
影响因子：
--
作者：
Evans, DA;Hebert, LE;Taylor, JO
通讯作者：
Taylor, JO
影响因子：
12.7
作者：
Brookmeyer, R;Gray, S;Kawas, C
通讯作者：
Kawas, C