Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet.
Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet.
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DOI：
10.1186/1743-7075-6-46
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发表时间：
2009-11-19
影响因子：
4.5
通讯作者：
Kinzig KP
中科院分区：
文献类型：
--
作者：
Honors MA;Davenport BM;Kinzig KP
生酮饮食已被用于减肥和改善代谢参数。本实验检查了长时间摄入生酮饮食后恢复普通饮食的影响。大鼠维持食物（CH）或生酮饮食（KD）8周，之后KD大鼠仅获得食物（KD：CH）另外8周。在饮食转换之前和之后测量卡路里摄入量、体重和血浆瘦素、胰岛素和生长激素释放肽。与CH对照组相比，摄入生酮饮食8周后，KD大鼠的肥胖和血浆瘦素水平增加，胰岛素水平降低。饮食转换后一周，脂肪垫重量和瘦素水平保持升高，并在饮食转换后8周内恢复正常。从KD转换为食物诱导了短暂的摄食量减少，使得KD：CH大鼠在饮食转换后的第一周期间消耗的卡路里显著少于CH大鼠消耗的卡路里。尽管在KD：CH大鼠中血浆ghrelin显著增加，但这种摄食减少。最后，KD：CH大鼠随着时间的推移出现了摄食过多，在饮食转换后的6-8周内，每天消耗的卡路里明显多于CH喂养的对照组，体重也比CH喂养的对照组增加。总的来说，这些数据表明，在食用生酮饮食一段时间后恢复以碳水化合物为基础的饮食对热量摄入、体重增加和胰岛素水平具有饮食后效应。
Ketogenic diets have been utilized for weight loss and improvement in metabolic parameters. The present experiments examined the effects of returning to a chow diet after prolonged ingestion of a ketogenic diet. Rats were maintained on chow (CH) or a ketogenic diet (KD) for 8 weeks, after which the KD rats were given access to chow only (KD:CH) for 8 additional weeks. Caloric intake, body weight, and plasma leptin, insulin and ghrelin were measured before and after the dietary switch. After 8 weeks of consuming a ketogenic diet, KD rats had increased adiposity and plasma leptin levels, and reduced insulin, as compared to CH controls. One week after the diet switch, fat pad weight and leptin levels remained elevated, and were normalized to CH controls within 8 weeks of the dietary switch. Switching from KD to chow induced a transient hypophagia, such that KD:CH rats consumed significantly fewer calories during the first week after the dietary switch, as compared to calories consumed by CH rats. This hypophagia was despite significantly increased plasma ghrelin in KD:CH rats. Finally, KD:CH rats developed hyperphagia over time, and during weeks 6-8 after the diet switch consumed significantly more calories per day than did CH-fed controls and gained more weight than CH-fed controls. Collectively, these data demonstrate that returning to a carbohydrate-based diet after a period of consuming a ketogenic diet has post-diet effects on caloric intake, body weight gain, and insulin levels.
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影响因子：
4.2
作者：
Al-Sarraj, Taif;Saadi, Hussein;Fernandez, Maria Luz
通讯作者：
Fernandez, Maria Luz
DOI：
10.1038/oby.2005.205
发表时间：
2005-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kinzig, KP;Scott, KA;Moran, TH
通讯作者：
Moran, TH
影响因子：
2.9
作者：
RAMIREZ, I
通讯作者：
RAMIREZ, I
影响因子：
4.2
作者：
THENEN, SW;MAYER, J
通讯作者：
MAYER, J
影响因子：
5.4
作者：
DELPRETE, E;SCHARRER, E
通讯作者：
SCHARRER, E