Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.
Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.
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DOI：
10.1037/pha0000179
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发表时间：
2018-06
影响因子：
2.3
通讯作者：
Donny EC
中科院分区：
文献类型：
--
作者：
Dermody SS;McClernon FJ;Benowitz N;Luo X;Tidey JW;Smith TT;Vandrey R;Hatsukami D;Donny EC
In the U.S., the FDA has initiated a public dialogue about reducing the nicotine content of cigarettes. A reduced-nicotine standard could increase withdrawal symptoms among current smokers. We examined the impact of switching smokers to cigarettes that varied in nicotine content on withdrawal symptoms over 6 weeks. A secondary analysis (N=839) of a 10-site, double-blind clinical trial of non-treatment seeking smokers was completed. Participants were instructed to smoke study cigarettes, containing 0.4 to 15.8 mg of nicotine/g of tobacco, for 6-weeks and were then abstinent overnight. Using latent growth curves, trajectories of individual withdrawal symptoms were compared between the reduced nicotine content (RNC) conditions and a normal nicotine content (NNC) condition. Path analyses compared symptoms after overnight abstinence. Relative to NNC cigarettes, participants smoking RNC cigarettes had increased anger/irritability/frustration and increased appetite/weight gain during the initial weeks, but the symptoms resolved by Week 6. Individuals who were biochemically-verified as adherent with using only the 0.4 mg/g cigarettes had higher sadness levels (Cohen’s d = .40) at Week 6 compared with the NNC condition, although symptoms were mild. After a post-Week 6 overnight abstinence challenge, some RNC conditions relative to NNC condition exhibited reduced withdrawal. Individuals who were biochemically-confirmed as adherent to the lowest nicotine condition experienced only mild and transient symptom elevations. Thus, a reduced-nicotine standard for cigarettes produced a relatively mild and temporary increase in withdrawal among non-treatment seeking smokers (ClinicalTrials.gov number, NCT01681875).
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影响因子：
4.2
作者：
Donny, Eric C.;Jones, Melissa
通讯作者：
Jones, Melissa
DOI：
10.1158/1055-9965.epi-12-1439
发表时间：
2013-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hatsukami DK;Hertsgaard LA;Vogel RI;Jensen JA;Murphy SE;Hecht SS;Carmella SG;al'Absi M;Joseph AM;Allen SS
通讯作者：
Allen SS
DOI：
10.1158/1055-9965.epi-11-0644
发表时间：
2012-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Benowitz NL;Dains KM;Hall SM;Stewart S;Wilson M;Dempsey D;Jacob P 3rd
通讯作者：
Jacob P 3rd
DOI：
10.1080/14622299050011121
发表时间：
1999-03-01
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Corrigall, W A
通讯作者：
Corrigall, W A
影响因子：
6
作者：
Hatsukami, Dorothy K.;Kotlyar, Michael;Hecht, Stephen S.
通讯作者：
Hecht, Stephen S.