Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway.
Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway.
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德氏乳杆菌发酵上清液通过 caspase 3 依赖性途径抑制人结肠癌细胞生长并诱导细胞凋亡
DOI：
10.3892/ol.2014.1959
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发表时间：
2014-05
期刊：
影响因子：
2.9
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Wan Y;Xin Y;Zhang C;Wu D;Ding D;Tang L;Owusu L;Bai J;Li W
已知益生菌对其动物宿主发挥广泛的有益作用。因此，本研究探讨德氏乳杆菌发酵上清液对结肠癌的作用。结果表明，LBF溶液处理的结肠癌SW 620细胞的增殖被阻滞，并以浓度依赖的方式积累在G1期。LBF溶液通过内源性caspase 3依赖性途径有效诱导细胞凋亡，并相应降低Bcl-2的表达。与结肠癌细胞侵袭相关的基质金属蛋白酶9的活性在LBF处理的细胞中也降低。总之，这些结果证明了LBF在体外的抗肿瘤作用，并可能有助于开发用于治疗结肠癌的新疗法。
Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored the effect of the supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) on colon cancer. The results indicated that the proliferation of LBF solution-treated colon cancer SW620 cells was arrested and accumulated in the G1 phase in a concentration-dependent manner. The LBF solution efficiently induced apoptosis through the intrinsic caspase 3-depedent pathway, with a corresponding decreased expression of Bcl-2. The activity of matrix metalloproteinase 9, which is associated with the invasion of colon cancer cells, was also decreased in the LBF-treated cells. In conclusion, the results demonstrate the antitumor effect of LBF in vitro and may contribute to the development of novel therapies for the treatment of colon cancer.
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影响因子：
14.5
作者：
Stetler-Stevenson, WG;Yu, AE
通讯作者：
Yu, AE
影响因子：
7.1
作者：
Wollowski, I;Rechkemmer, G;Pool-Zobel, BL
通讯作者：
Pool-Zobel, BL
影响因子：
50.5
作者：
Kanavos, P.
通讯作者：
Kanavos, P.
DOI：
10.1080/01635581.2012.700758
发表时间：
2012-01-01
影响因子：
2.9
作者：
Escamilla, Juanita;Lane, Michelle A.;Maitin, Vatsala
通讯作者：
Maitin, Vatsala
影响因子：
5.3
作者：
Decock J;Thirkettle S;Wagstaff L;Edwards DR
通讯作者：
Edwards DR