Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs.
Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs.
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DOI：
10.1186/1746-6148-10-57
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发表时间：
2014-03-05
影响因子：
2.6
通讯作者：
Arai T
中科院分区：
文献类型：
--
作者：
Kawasumi K;Kashiwado N;Okada Y;Sawamura M;Sasaki Y;Iwazaki E;Mori N;Yamamoto I;Arai T
近年来，在犬中，脂质代谢紊乱如肥胖和糖尿病的发生显著增加。高脂血症被认为是肥胖动物的共同特征，高脂血症状态可能与炎症、氧化应激和脂质组成变化有关。本研究观察了24只犬（青年组：0-7岁，n = 12;老年组：8-13岁，n = 12）血浆胆固醇和甘油三酯（TG）谱及代谢物浓度的变化。老年犬血浆脂联素（adiponectin，ADN）浓度显著低于青年犬（均值±标准差分别为17.2 ± 10.0 μg mL-1和29.3 ± 12.5 μg mL-1，P <0.05）。尽管在统计学上没有显著差异，但老年犬的血浆α 1-酸性糖蛋白（alpah 1-AG）水平显著高于年轻犬。用双向琼脂糖凝胶电泳技术将血浆胆固醇脂蛋白和甘油三酯脂蛋白分为四个组分。老年犬的正极第三个TG脂蛋白组分（TG组分3）水平显着高于年轻犬（平均值± SD，分别为143.0 ± 109.3 mg dL-1和55.2 ± 31.3 mg dL-1; P <0.05）。用Peason法进行相关系数分析，年龄与TG呈中度正相关（r = 0.446，P = 0.029），TG组分3丙二醛（r = 0.146，P = 0.043）、α 1 AG（r = 0.448，P = 0.028）水平。年龄与总胆固醇（TC）组分2（r =-0.446，P = 0.029）、血糖（r =-0.637，P = 0.001）、ADN（r =-0.408，P = 0.048）呈中度负相关。目前的数据表明，脂质代谢紊乱的生化特征可能会受到影响，在狗的老化。
In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the changes in plasma cholesterol and triglyceride (TG) profiles and metabolite concentrations in 24 dogs (young group: 0-7 years old, n = 12, aged group: 8-13 years old, n = 12). Plasma adiponectin (ADN) concentrations were significantly lower in aged dogs than those in young dogs (mean ± SD, 17.2 ± 10.0 μg mL-1 vs 29.3 ± 12.5 μg mL-1, respectively; P <0.05). Although there were no significant differences statistically, aged dogs showed significantly higher plasma alpha1- acid glycoprotein (alpah1-AG) levels compared to those in young dogs. Plasma cholesterol lipoprotein and TG lipoprotein were divided into four fractions by biphasic agarose gel electrophoresis technique. The levels of the third TG-lipoprotein fraction from the positive pole (TG Fraction 3) were significantly higher in aged dogs than in young dogs (mean ± SD, 143.0 ± 109.3 mg dL-1 vs 55.2 ± 31.3 mg dL-1, respectively; P <0.05). On the correlation coefficient analysis by Peason’s method, moderate positive correlations were seen between the age and TG (r = 0.446, P = 0.029), TG Fraction 3 (r = 0.516, P = 0.010), malondialdehyde (r = 0.146, P = 0.043), alpha-1 AG (r = 0.448, P = 0.028) levels, respectively. Moderate negative correlations were seen the age and total cholesterol (TC) Fraction 2 (r = -0.446, P = 0.029), glucose (r = -0.637, P = 0.001), ADN (r = -0.408, P = 0.048), respectively. Present data suggest biochemical characteristics of lipid metabolism disorder may be affected by aging in dogs.
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影响因子：
2.2
作者：
Mori, Nobuko;Lee, Peter;Arai, Toshiro
通讯作者：
Arai, Toshiro
影响因子：
2.6
作者：
Macotpet, Arayaporn;Suksawat, Fanan;Boonsiri, Patcharee
通讯作者：
Boonsiri, Patcharee
DOI：
10.1016/0006-2944(81)90096-x
发表时间：
1981-01-01
期刊：
BIOCHEMICAL MEDICINE
影响因子：
--
作者：
NISHIGAKI, I;HAGIHARA, M;YAGI, K
通讯作者：
YAGI, K
体重减轻对2型糖尿病患者脂肪细胞大小亚分离的差异影响。
影响因子：
6.9
作者：
Pasarica, Magdalena;Tchoukalova, Yourka D.;Heilbronn, Leonie K.;Fang, Xiaobing;Albu, Jeanine B.;Kelley, David E.;Smith, Smith R.;Ravussin, Eric
通讯作者：
Ravussin, Eric
影响因子：
2.4
作者：
Mori, N.;Lee, P.;Arai, T.
通讯作者：
Arai, T.