Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation.
Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation.
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DOI：
10.1101/lm.036947.114
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Freeman JH
中科院分区：
文献类型：
--
作者：
Halverson HE;Poremba A;Freeman JH
联想学习任务通常涉及听觉刺激，听觉刺激必须通过听觉系统投射到记忆诱导部位，以进行学习。耳蜗核（CN）到脑桥核的投射被认为是小脑学习（包括眨眼条件反射）的必要听觉通路。然而，内侧听觉丘脑核（MATN），包括内侧膝状体，膝上体，和后层间核的内侧部也被牵连作为一个关键的听觉中继桥核小脑依赖的运动学习。MATN还将听觉信息传递给杏仁核，这是回避和恐惧条件反射所必需的。目前的研究使用CN刺激增加脑桥核的活动，相对于音调刺激，并可能提供足够的输入到小脑的收购或保留的眨眼条件在MATN失活。使用2-脱氧葡萄糖放射自显影检查CN刺激和MATN失活的主要和次要影响。CN的刺激增加活动在脑桥核，然而，这种增加是不够的，在MATN失活小脑学习。目前的实验结果提供了额外的证据表明，MATN可能是许多联想学习任务的关键听觉中继。
Associative learning tasks commonly involve an auditory stimulus, which must be projected through the auditory system to the sites of memory induction for learning to occur. The cochlear nucleus (CN) projection to the pontine nuclei has been posited as the necessary auditory pathway for cerebellar learning, including eyeblink conditioning. However, the medial auditory thalamic nuclei (MATN), consisting of the medial division of the medial geniculate, suprageniculate, and posterior interlaminar nucleus have also been implicated as a critical auditory relay to the pontine nuclei for cerebellum-dependent motor learning. The MATN also conveys auditory information to the amygdala necessary for avoidance and fear conditioning. The current study used CN stimulation to increase activity in the pontine nuclei, relative to a tone stimulus, and possibly provide sufficient input to the cerebellum for acquisition or retention of eyeblink conditioning during MATN inactivation. Primary and secondary effects of CN stimulation and MATN inactivation were examined using 2-deoxy-glucose autoradiography. Stimulation of CN increased activity in the pontine nuclei, however, this increase was not sufficient for cerebellar learning during MATN inactivation. Results of the current experiment provide additional evidence indicating the MATN may be the critical auditory relay for many associative learning tasks.
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影响因子：
2
作者：
Freeman, John H.;Halverson, Hunter E.;Hubbard, Erin M.
通讯作者：
Hubbard, Erin M.
影响因子：
2.7
作者：
GONZALEZLIMA, F;SCHEICH, H
通讯作者：
SCHEICH, H
影响因子：
2
作者：
Halverson, Hunter E.;Freeman, John H.
通讯作者：
Freeman, John H.
DOI：
10.1101/lm.1002508
发表时间：
2008-07
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Halverson HE;Poremba A;Freeman JH
通讯作者：
Freeman JH
影响因子：
16.2
作者：
Hesslow, G;Svensson, P;Ivarsson, M
通讯作者：
Ivarsson, M