Functional magnetic resonance imaging of auditory cortical fields in awake marmosets.
Functional magnetic resonance imaging of auditory cortical fields in awake marmosets.
复制标题
DOI：
10.1016/j.neuroimage.2017.08.052
复制
发表时间：
2017-11-15
期刊：
影响因子：
5.7
通讯作者：
Silva AC
中科院分区：
文献类型：
--
作者：
Toarmino CR;Yen CCC;Papoti D;Bock NA;Leopold DA;Miller CT;Silva AC
灵长类动物的听觉皮层被组织成一个解剖学上和功能上不同的处理领域的网络。由于听觉核心区的音调定位特性，它一直是从感觉编码到知觉决策的神经生理学研究的主要目标。相比之下，对听觉带的研究较少，部分原因是听觉带区域的神经元更喜欢更复杂的刺激，并且比核心区域的神经元更喜欢单一频率的纯音。功能性磁共振成像（fMRI）等补充方法允许对听觉核心和听觉带进行解剖学识别，并通过同时快速测试多个大脑区域的一系列刺激来促进其功能表征，这些刺激可用于指导后续的神经记录。在灵长类动物中桥接这些技术将有助于进一步扩大我们对灵长类动物听觉的理解。在这里，我们开发了一种新的准备，以测试是否可以使用功能磁共振成像在普通绒猴（Callithrix jacchus），一个强大的灵长类动物听觉系统的模型识别听觉皮层的不同区域。我们使用了两种类型的刺激，带通噪声和纯音，解析除了周围的次级带场的听觉核心。与大多数灵长类动物的听觉功能磁共振成像实验相反，我们采用了连续采样范式来快速收集数据，几乎没有有害影响。在这里，我们发现强大的双边听觉皮层激活两只绒猴和单侧激活第三次利用这种准备。此外，我们证实了先前报道的结果在电生理学实验中，如tonotopic组织的听觉核心和地区激活优先复杂的简单刺激。总的来说，这些数据建立了一个关键的准备，为未来的研究，以探讨各种功能特性的绒猴听觉皮层。
The primate auditory cortex is organized into a network of anatomically and functionally distinct processing fields. Because of its tonotopic properties, the auditory core has been the main target of neurophysiological studies ranging from sensory encoding to perceptual decision-making. By comparison, the auditory belt has been less extensively studied, in part due to the fact that neurons in the belt areas prefer more complex stimuli and integrate over a wider frequency range than neurons in the core, which prefer pure tones of a single frequency. Complementary approaches, such as functional magnetic resonance imaging (fMRI), allow the anatomical identification of both the auditory core and belt and facilitate their functional characterization by rapidly testing a range of stimuli across multiple brain areas simultaneously that can be used to guide subsequent neural recordings. Bridging these technologies in primates will serve to further expand our understanding of primate audition. Here, we developed a novel preparation to test whether different areas of the auditory cortex could be identified using fMRI in common marmosets (Callithrix jacchus), a powerful model of the primate auditory system. We used two types of stimulation, band pass noise and pure tones, to parse apart the auditory core from surrounding secondary belt fields. In contrast to most auditory fMRI experiments in primates, we employed a continuous sampling paradigm to rapidly collect data with little deleterious effects. Here we found robust bilateral auditory cortex activation in two marmosets and unilateral activation in a third utilizing this preparation. Furthermore, we confirmed results previously reported in electrophysiology experiments, such as the tonotopic organization of the auditory core and regions activating preferentially to complex over simple stimuli. Overall, these data establish a key preparation for future research to investigate various functional properties of marmoset auditory cortex.
登录
查看更多内容
影响因子：
5.7
作者：
Humphries, Colin;Liebenthal, Einat;Binder, Jeffrey R.
通讯作者：
Binder, Jeffrey R.
影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
5.7
作者：
Hung CC;Yen CC;Ciuchta JL;Papoti D;Bock NA;Leopold DA;Silva AC
通讯作者：
Silva AC
影响因子：
5.7
作者：
Liu, Junjie V.;Hirano, Yoshiyuki;Nascimento, George C.;Stefanovic, Bojana;Leopold, David A.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
16.2
作者：
Miller CT;Freiwald WA;Leopold DA;Mitchell JF;Silva AC;Wang X
通讯作者：
Wang X