Elucidating behavioral and functional connectivity markers of aberrant threat discrimination in PTSD.
Elucidating behavioral and functional connectivity markers of aberrant threat discrimination in PTSD.
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DOI：
10.1002/da.23295
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发表时间：
2022-12
影响因子：
7.4
通讯作者：
Neria, Yuval
中科院分区：
文献类型：
--
作者：
Keefe, John R.;Suarez-Jimenez, Benjamin;Zhu, Xi;Lazarov, Amit;Durosky, Ariel;Such, Sara;Marohasy, Caroline;Lissek, Shmuel;Neria, Yuval
创伤后应激障碍（PTSD）患者倾向于将威胁过度概括为安全刺激，这可能反映了异常的刺激歧视。然而，威胁过度概括是否反映了普遍的歧视缺陷，或者更确切地说，是一种与厌恶刺激相关的特定偏见，目前尚不清楚。在这里，我们测试了这个问题，并描述了威胁辨别的神经关联。108名参与者（33名创伤后应激障碍患者，43名创伤暴露对照组，32名健康对照组）完成了一项情绪中立的复杂形状辨别任务，包括识别42对相似的先前观察到的形状；情绪厌恶歧视任务，包括提供厌恶条件刺激（CS+）的风险评级，以及与原始CS+大小逐渐不同的几种刺激的风险评级。在完成任务之前收集静息状态功能连接（rsFC）。在情绪中立的任务中，没有出现组间差异。相反，在情绪厌恶任务中，PTSD患者的线性风险评级斜率更陡，因为刺激更像条件刺激。最后，杏仁核-默认模式网络（DMN）和DMN-突出网络（SN）的rsFC较低与更陡的风险斜率相关，而海马-SN的rsFC较低仅在PTSD患者中发现。PTSD患者只有在面对厌恶刺激时才表现出歧视的缺陷。失调的辨别模式可能与缺乏从调节脑区（如DMN/海马）到威胁相关脑区（如SN/杏仁核）的输入有关。
Patients with posttraumatic stress disorder (PTSD) tend to over-generalize threat to safe stimuli, potentially reflecting aberrant stimuli discrimination. Yet, it is not clear whether threat overgeneralization reflects general discrimination deficits, or rather a specific bias related to aversive stimuli. Here we tested this question and characterized the neural correlates of threat discrimination. One-hundred and eight participants (33 PTSD; 43 trauma-exposed controls; 32 healthy controls) completed an emotionally neutral complex shape discrimination task involving identifying in 42 similar pairs the previously observed shape; and an emotionally aversive discrimination task, involving providing risk ratings for an aversive conditioned stimulus (CS+), and for several stimuli gradually differing in size from the original CS+. Resting state functional connectivity (rsFC) was collected before completing the tasks. No group differences emerged on the emotionally neutral task. Conversely, on the emotionally aversive task, individuals with PTSD had steeper linear risk rating slopes as the stimuli more resembled the conditioned stimulus. Finally, lower rsFC of amygdala-default mode network (DMN) and DMN-salience network (SN) were associated with steeper risk slopes, while for hippocampus-SN, lower rsFC was found only among participants with PTSD. Individuals with PTSD show deficits in discrimination only when presented with aversive stimuli. Dysregulated discrimination pattern may relate to a lack of input from regulatory brain areas (e.g., DMN/hippocampus) to threat-related brain areas (e.g., SN/amygdala).
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影响因子：
4.8
作者：
Lazarov A;Zhu X;Suarez-Jimenez B;Rutherford BR;Neria Y
通讯作者：
Neria Y
影响因子：
4.7
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
通讯作者：
Davis M
从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
DOI：
10.1073/pnas.1400335111
发表时间：
2014-02-25
影响因子：
11.1
作者：
LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.
影响因子：
25
作者：
Brickman AM;Khan UA;Provenzano FA;Yeung LK;Suzuki W;Schroeter H;Wall M;Sloan RP;Small SA
通讯作者：
Small SA