Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.
Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.
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DOI：
10.1016/j.bpsgos.2023.10.002
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发表时间：
2024-01
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影响因子：
--
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中科院分区：
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社区或地区一级的社会经济劣势与整个生命周期的神经改变有关。然而，很少有研究探讨了在青春期，一个重要的发展时期，与精神病理学的风险增加相一致的白色物质微观结构的邻里劣势的影响。在200名青少年（年龄13-20岁; 54.5%女性，4%非二元）从2项研究中招募丰富的早期逆境和抑郁症，我们研究了是否邻里社会经济劣势来自人口普查区数据与白色物质微结构在几个主要的白色物质束。我们还研究了抑郁症状和性别是否会调节这些关联。更大的社区社会经济劣势与左侧弓状束（β =-0.24，错误发现率[FDR]校正p = 0.035）和右侧钩状束（β =-0.32，FDR校正p = 0.002）的较低各向异性分数（FA）相关，高于家庭水平社会经济地位的影响。抑郁症状显著调节了左侧弓状束FA与邻居（β = 0.17，FDR校正的p = 0.026）和失业（β = 0.22，FDR校正的p = 0.004）劣势之间的关联，因此这些关联仅在报告抑郁程度较轻的青少年中显著。性别没有缓和的社会经济劣势和FA在这些大片之间的关联。更大的邻里社会经济的劣势，特别是贫困和教育程度的水平，与较低的FA在弓状束和钩束以上，超越家庭层面的社会经济地位的措施的影响。这些模式仅在抑郁水平较低的青少年中观察到，这表明我们必须谨慎地将这些发现推广到患有心理健康问题的青少年。
Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coincides with increased risk for psychopathology. In 200 adolescents (ages 13–20 years; 54.5% female, 4% nonbinary) recruited from 2 studies enriched for early adversity and depression, we examined whether neighborhood socioeconomic disadvantage derived from census tract data was related to white matter microstructure in several major white matter tracts. We also examined whether depressive symptoms and sex moderated these associations. Greater neighborhood socioeconomic disadvantage was associated with lower fractional anisotropy (FA) in the left arcuate fasciculus (β = −0.24, false discovery rate [FDR]–corrected p = .035) and right uncinate fasciculus (β = −0.32, FDR-corrected p = .002) above and beyond the effects of family-level socioeconomic status. Depressive symptoms significantly moderated the association between left arcuate fasciculus FA and both neighborhood (β = 0.17, FDR-corrected p = .026) and unemployment (β = 0.22, FDR-corrected p = .004) disadvantage such that these associations were only significant in adolescents who reported less severe depression. Sex did not moderate the association between socioeconomic disadvantage and FA in these tracts. Greater neighborhood socioeconomic disadvantage, particularly poverty and educational attainment levels, was associated with lower FA in the arcuate fasciculus and uncinate fasciculus above and beyond the effects of family-level measures of socioeconomic status. These patterns were only observed in adolescents with low levels of depression, suggesting that we must be cautious about generalizing these findings to youths who struggle with mental health difficulties.
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影响因子：
25
作者：
Noble, Kimberly G.;Houston, Suzanne M.;Brito, Natalie H.;Bartsch, Hauke;Kan, Eric;Kuperman, Joshua M.;Akshoomoff, Natacha;Amaral, David G.;Bloss, Cinnamon S.;Libiger, Ondrej;Schork, Nicholas J.;Murray, Sarah S.;Casey, B. J.;Chang, Linda;Ernst, Thomas M.;Frazier, Jean A.;Gruen, Jeffrey R.;Kennedy, David N.;Van Zijl, Peter;Mostofsky, Stewart;Kaufmann, Walter E.;Kenet, Tal;Dale, Anders M.;Jernigan, Terry L.;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
DOI：
10.1016/j.jaac.2014.04.021
发表时间：
2014-08
影响因子：
13.3
作者：
LeWinn, Kaja Z.;Connolly, Colm G.;Wu, Jing;Drahos, Miroslav;Hoeft, Fumiko;Ho, Tiffany C.;Simmons, Alan N.;Yang, Tony T.
通讯作者：
Yang, Tony T.
影响因子：
5.4
作者：
Browning, Christopher R.;Soller, Brian;Jackson, Aubrey L.
通讯作者：
Jackson, Aubrey L.
影响因子：
3.3
作者：
Kircanski, Katharina;Sisk, Lucinda M.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
影响因子：
7.6
作者：
Ho, Tiffany C.;Sisk, Lucinda M.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.