Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
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DOI：
10.1186/1475-2840-12-170
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发表时间：
2013-11-13
影响因子：
9.3
通讯作者：
Devlin AM
中科院分区：
文献类型：
--
作者：
Sulistyoningrum DC;Gasevic D;Lear SA;Ho J;Mente A;Devlin AM
胰岛素抵抗(IR)的种族差异得到了很好的描述，但潜在的机制尚不清楚。脂联素是一种胰岛素增敏脂肪细胞因子，以多种异构体的形式循环，其中高分子量的脂联素与最大的胰岛素敏感性有关。这项研究的目的是确定血浆总脂联素和HMW脂联素浓度是否是导致IR的种族差异的原因。对健康的加拿大原住民、中国人、欧洲人和南亚成年人(N = 634)进行了社会人口学、生活方式、空腹血浆胰岛素、血糖、总脂联素和高分子脂联素；以及肥胖测量[体重指数、腰围、腰臀比、体脂百分比以及皮下和内脏脂肪组织(通过计算机断层扫描量化)]的评估。稳态模型评估-胰岛素抵抗(HOMA-IR)评估IR。南亚人的HOMA-IR最高，其次是原住民、中国人和欧洲人(P <； 0.001)。中国人和南亚人的血浆总脂联素和高分子脂联素浓度低于土著和欧洲人(P <； 0.05)。总脂联素和高分子脂联素与HOMA-IR呈负相关(P <； 0.001)。种族改变了高分子脂联素和HOMA-IR之间的关系，与欧洲人相比，在土著人(P = 0.001)、中国人(P = 0.002)和南亚人(P = 0.040)中观察到更强的影响。而对于总脂联素则没有观察到这一点(P = 0.431)。在平均总脂联素浓度上，南亚人的HOMA-IR高于欧洲人(P <； 0.001)。HMW脂联素浓度每降低一次，原住民、中国人和南亚人的HOMA-IR增加幅度就比欧洲人大。HMW脂联素的种族差异可能解释了IR的差异。
Ethnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) adiponectin associated with greatest insulin sensitivity. The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR. Healthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR. South Asians had the greatest HOMA-IR, followed by Aboriginals, Chinese, and Europeans (P < 0.001). Plasma total and HMW adiponectin concentrations were lower in Chinese and South Asians than Aboriginal and Europeans (P < 0.05). Total and HMW adiponectin were inversely associated with HOMA-IR (P < 0.001). Ethnicity modified the relationship between HMW adiponectin and HOMA-IR with stronger effects observed in Aboriginals (P = 0.001), Chinese (P = 0.002), and South Asians (P = 0.040) compared to Europeans. This was not observed for total adiponectin (P = 0.431). At mean total adiponectin concentrations South Asians had higher HOMA-IR than Europeans (P < 0.001). For each given decrease in HMW adiponectin concentrations a greater increase in HOMA-IR is observed in Aboriginals, Chinese, and South Asians than Europeans. Ethnic-specific differences in HMW adiponectin may account for differences in IR.
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影响因子：
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作者：
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通讯作者：
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