Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA).
Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA).
复制标题
DOI：
10.1289/ehp.0901827
复制
发表时间：
2010-08
影响因子：
10.4
通讯作者：
Savitz DA
中科院分区：
文献类型：
--
作者：
Steenland K;Fletcher T;Savitz DA
我们回顾了PFOA的流行病学文献。全氟辛酸（PFOA）不是天然存在的，但存在于工业化国家大多数居民的血清中（美国中位数，4 ng/mL）。饮用水是某些人群的主要接触途径，但对接触源了解不多。PFOA已被用于生产Gore-Tex和Teflon等产品。PFOA不会在环境中分解;人类半衰期估计约为3年。PFOA不会在体内代谢;它不是亲脂性的。PFOA没有直接的遗传毒性;动物数据表明，它可以导致几种类型的肿瘤和新生儿死亡，并可能对免疫，肝脏和内分泌系统产生毒性作用。关于全氟辛酸对人类健康影响的数据很少。有相对一致的证据表明与胆固醇和尿酸存在适度的正相关性，尽管胆固醇效应的大小在不同的暴露水平上不一致。有一些但不太一致的证据表明与肝酶呈适度正相关。大多数发现来自横截面研究，限制了结论。两项职业队列研究没有提供一致的慢性病证据;两者都受到样本量和依赖死亡率数据的限制。生殖数据最近有所增加，但不一致，任何观察到的不利影响是适度的。流行病学证据仍然有限，迄今为止的数据不足以得出关于PFOA对任何关注疾病的作用的确切结论。
We reviewed the epidemiologic literature for PFOA. Perfluorooctanoic acid (PFOA) does not occur naturally but is present in the serum of most residents of industrialized countries (U.S. median, 4 ng/mL). Drinking water is the primary route of exposure in some populations, but exposure sources are not well understood. PFOA has been used to manufacture such products as Gore-Tex and Teflon. PFOA does not break down in the environment; the human half-life is estimated at about 3 years. PFOA is not metabolized in the body; it is not lipophilic. PFOA is not directly genotoxic; animal data indicate that it can cause several types of tumors and neonatal death and may have toxic effects on the immune, liver, and endocrine systems. Data on the human health effects of PFOA are sparse. There is relatively consistent evidence of modest positive associations with cholesterol and uric acid, although the magnitude of the cholesterol effect is inconsistent across different exposure levels. There is some but much less consistent evidence of a modest positive correlation with liver enzymes. Most findings come from cross-sectional studies, limiting conclusions. Two occupational cohort studies do not provide consistent evidence for chronic disease; both are limited by sample size and reliance on mortality data. Reproductive data have increased recently but are inconsistent, and any observed adverse effects are modest. Epidemiologic evidence remains limited, and to date data are insufficient to draw firm conclusions regarding the role of PFOA for any of the diseases of concern.
登录
查看更多内容
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
影响因子：
5
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
2.9
作者：
Bloom, Michael S.;Kannan, Kurunthachalam;Vena, John E.
通讯作者：
Vena, John E.
影响因子：
10.4
作者：
Fei C;McLaughlin JK;Lipworth L;Olsen J
通讯作者：
Olsen J