Cortical activity evoked by an acute painful tissue-damaging stimulus in healthy adult volunteers.
Cortical activity evoked by an acute painful tissue-damaging stimulus in healthy adult volunteers.
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DOI：
10.1152/jn.00990.2012
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发表时间：
2013-05
影响因子：
2.5
通讯作者：
Fitzgerald M
中科院分区：
文献类型：
--
作者：
Fabrizi L;Williams G;Lee A;Meek J;Slater R;Olhede S;Fitzgerald M
日常疼痛经历通常是伴随组织损伤的单一事件，但大多数大脑皮肤伤害性处理的实验研究都使用不会损伤皮肤的重复激光、热或电刺激。在这项研究中，通过脑电图 (EEG) 对 20 名年龄 21-40 岁的健康成年志愿者（13 名男性和 7 名女性）进行了由组织损伤性皮肤矛引起的大脑伤害性活动的分析。诱发活动的时频分析揭示了 100-300 ms 时明显的晚期事件相关顶点电位（矛事件相关电位，LERP），由 1 至 20 Hz 之间的锁相能量增加（δ-β 频带）组成。喷枪和假控制刺激之间的成对比较也揭示了在 Delta 频带（1-5 Hz）中喷枪之后一段超强的去同步化。刺破前在皮肤上涂抹芥子油，可以使表达阳离子通道 TRPA1 的伤害感受器亚群敏感，不会影响超极去同步化，但会减少 δ 和 β 带的锁相能量增加，表明伤害感受输入的不同方式之间存在中心相互作用。对个体疼痛经历的口头描述筛选显示，矛状疼痛主要是由于 Aδ 纤维激活引起的，但当个体将矛状疼痛描述为 C 纤维介导时，大脑诱发的活动中会发生与事件相关的超晚期 δ 带去同步化。我们得出的结论是，急性组织损伤引起的疼痛与大脑中脑电图振荡的不同 Aδ 和 C 纤维介导的同步和去同步模式有关。
Everyday painful experiences are usually single events accompanied by tissue damage, and yet most experimental studies of cutaneous nociceptive processing in the brain use repeated laser, thermal, or electrical stimulations that do not damage the skin. In this study the nociceptive activity in the brain evoked by tissue-damaging skin lance was analyzed with electroencephalography (EEG) in 20 healthy adult volunteers (13 men and 7 women) aged 21–40 yr. Time-frequency analysis of the evoked activity revealed a distinct late event-related vertex potential (lance event-related potential, LERP) at 100–300 ms consisting of a phase-locked energy increase between 1 and 20 Hz (delta-beta bands). A pairwise comparison between lance and sham control stimulation also revealed a period of ultralate stronger desynchronization after lance in the delta band (1–5 Hz). Skin application of mustard oil before lancing, which sensitizes a subpopulation of nociceptors expressing the cation channel TRPA1, did not affect the ultralate desynchronization but reduced the phase-locked energy increase in delta and beta bands, suggesting a central interaction between different modalities of nociceptive inputs. Verbal descriptor screening of individual pain experience revealed that lance pain is predominantly due to Aδ fiber activation, but when individuals describe lances as C fiber mediated, an ultralate delta band event-related desynchronization occurs in the brain-evoked activity. We conclude that pain evoked by acute tissue damage is associated with distinct Aδ and C fiber-mediated patterns of synchronization and desynchronization of EEG oscillations in the brain.
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DOI：
10.1016/s1082-3174(98)70001-7
发表时间：
1998-12-01
期刊：
PAIN FORUM
影响因子：
--
作者：
Chen, ACN;Arendt-Nielsen, L;Plaghki, L
通讯作者：
Plaghki, L
影响因子：
2.2
作者：
Harkins, SW;Price, DD;Fei, DY
通讯作者：
Fei, DY
DOI：
10.1016/0168-5597(89)90019-1
发表时间：
1989-03-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
KAKIGI, R;SHIBASAKI, H;IKEDA, A
通讯作者：
IKEDA, A
影响因子：
1.7
作者：
GarciaLarrea, L;Peyron, R;Mauguiere, F
通讯作者：
Mauguiere, F
影响因子：
9.2
作者：
Fabrizi, Lorenzo;Slater, Rebeccah;Worley, Alan;Meek, Judith;Boyd, Stewart;Olhede, Sofia;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria