No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population.
No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population.
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DOI：
10.1371/journal.pone.0084154
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Jeukendrup AE
中科院分区：
文献类型：
--
作者：
Killer SC;Blannin AK;Jeukendrup AE
人们常常认为咖啡会导致脱水，为了保持体液平衡，应该避免饮用咖啡或大幅减少摄入量。本研究的目的是通过一系列经过验证的水合作用评估技术，直接比较饮用咖啡和饮水的效果。在一项平衡交叉设计实验中，50名男性咖啡饮用者（习惯每天饮用3 - 6杯咖啡）参与了两项试验，每项试验持续三天。除了对体力活动、食物和液体摄入进行控制外，参与者要么饮用4份200毫升含4毫克/千克咖啡因的咖啡（C组），要么饮用等量的水（W组）。通过摄入氧化氘在试验前后计算总体水（TBW）。除了测量裸体体重（BM）外，每天还记录尿液和血液的水合标志物。分析血浆中的咖啡因以确认依从性。在两项试验中，从开始到结束总体水均无显著变化，且两组试验之间也无差异（C组和W组分别为51.5±1.4千克和51.4±1.3千克）。在任何血液标志物方面，以及24小时尿量（C组和W组分别为2409±660毫升和2428±669毫升）、尿比重（USG）、渗透压或肌酐方面，两组试验均未观察到差异。C组的平均尿钠排泄量高于W组（p = 0.02）。虽然在两项试验中都观察到体重每日有小幅逐渐下降（0.4±0.5千克；p<0.05），但不同条件下体重并无显著差异。我们的数据显示，在两项试验之间，在血液和尿液的多种水合状态标志物方面均无显著差异。这些数据表明，对于习惯摄入咖啡因的男性来说，适量饮用咖啡具有与饮水相似的补水效果。
It is often suggested that coffee causes dehydration and its consumption should be avoided or significantly reduced to maintain fluid balance. The aim of this study was to directly compare the effects of coffee consumption against water ingestion across a range of validated hydration assessment techniques. In a counterbalanced cross-over design, 50 male coffee drinkers (habitually consuming 3–6 cups per day) participated in two trials, each lasting three consecutive days. In addition to controlled physical activity, food and fluid intake, participants consumed either 4×200 mL of coffee containing 4 mg/kg caffeine (C) or water (W). Total body water (TBW) was calculated pre- and post-trial via ingestion of Deuterium Oxide. Urinary and haematological hydration markers were recorded daily in addition to nude body mass measurement (BM). Plasma was analysed for caffeine to confirm compliance. There were no significant changes in TBW from beginning to end of either trial and no differences between trials (51.5±1.4 vs. 51.4±1.3 kg, for C and W, respectively). No differences were observed between trials across any haematological markers or in 24 h urine volume (2409±660 vs. 2428±669 mL, for C and W, respectively), USG, osmolality or creatinine. Mean urinary Na+ excretion was higher in C than W (p = 0.02). No significant differences in BM were found between conditions, although a small progressive daily fall was observed within both trials (0.4±0.5 kg; p<0.05). Our data show that there were no significant differences across a wide range of haematological and urinary markers of hydration status between trials. These data suggest that coffee, when consumed in moderation by caffeine habituated males provides similar hydrating qualities to water.
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影响因子：
3.6
作者：
Perrier, Erica;Vergne, Sebastien;Klein, Alexis;Poupin, Marie;Rondeau, Pascale;Le Bellego, Laurent;Armstrong, Lawrence E;Lang, Florian;Stookey, Jodi;Tack, Ivan
通讯作者：
Tack, Ivan
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1123/ijsnem.15.3.252
发表时间：
2005-06-01
影响因子：
2.5
作者：
Armstrong, LE;Pumerantz, AC;Kellogg, M
通讯作者：
Kellogg, M
甲基黄嘌呤和肾脏。
影响因子：
--
作者：
Osswald, Hartmut;Schnermann, Jurgen
通讯作者：
Schnermann, Jurgen
影响因子：
3.4
作者：
Currell, Kevin;Urch, Joanna;Jeukendrup, Asker E.
通讯作者：
Jeukendrup, Asker E.