Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
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DOI：
10.1093/cercor/bhad427
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发表时间：
2024-01-14
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
闭环直接脑刺激是调节神经活动和行为的有前途的工具。然而，目前仍不清楚如何最佳地靶向刺激以调节特定认知功能的特定大脑网络中的大脑活动。在这里，我们测试的假设，刺激的行为和生理效应取决于刺激目标的解剖和功能网络属性。我们对47名神经外科患者进行闭环刺激，让他们学习和回忆单词列表。多变量分类器，训练来预测记忆功能的瞬间失误，在任务的研究阶段触发了外侧颞叶皮层（LTC）的刺激。我们发现，LTC刺激，特别是改善记忆时，提供给目标附近的白色途径。记忆力的改善是最大的目标附近的白色的问题，也显示出高功能连接到大脑的记忆网络。这些目标还减少了该网络中的低频活动，这是成功记忆编码的既定标志。这些数据揭示了解剖和功能网络如何介导刺激的行为和生理效应，提供了闭环LTC刺激可以改善情景记忆的进一步证据，并提出了一种通过改善刺激靶向来优化神经调节的方法。
Closed-loop direct brain stimulation is a promising tool for modulating neural activity and behavior. However, it remains unclear how to optimally target stimulation to modulate brain activity in particular brain networks that underlie particular cognitive functions. Here, we test the hypothesis that stimulation’s behavioral and physiological effects depend on the stimulation target’s anatomical and functional network properties. We delivered closed-loop stimulation as 47 neurosurgical patients studied and recalled word lists. Multivariate classifiers, trained to predict momentary lapses in memory function, triggered the stimulation of the lateral temporal cortex (LTC) during the study phase of the task. We found that LTC stimulation specifically improved memory when delivered to targets near white matter pathways. Memory improvement was largest for targets near white matter that also showed high functional connectivity to the brain’s memory network. These targets also reduced low-frequency activity in this network, an established marker of successful memory encoding. These data reveal how anatomical and functional networks mediate stimulation’s behavioral and physiological effects, provide further evidence that closed-loop LTC stimulation can improve episodic memory, and suggest a method for optimizing neuromodulation through improved stimulation targeting.
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DOI：
10.1016/j.cub.2017.03.028
发表时间：
2017-05-08
期刊：
Current biology : CB
影响因子：
--
作者：
Ezzyat Y;Kragel JE;Burke JF;Levy DF;Lyalenko A;Wanda P;O'Sullivan L;Hurley KB;Busygin S;Pedisich I;Sperling MR;Worrell GA;Kucewicz MT;Davis KA;Lucas TH;Inman CS;Lega BC;Jobst BC;Sheth SA;Zaghloul K;Jutras MJ;Stein JM;Das SR;Gorniak R;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
16.6
作者：
Ezzyat Y;Wanda PA;Levy DF;Kadel A;Aka A;Pedisich I;Sperling MR;Sharan AD;Lega BC;Burks A;Gross RE;Inman CS;Jobst BC;Gorenstein MA;Davis KA;Worrell GA;Kucewicz MT;Stein JM;Gorniak R;Das SR;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
5.7
作者：
Crocker, Britni;Ostrowski, Lauren;Paulk, Angelique C.
通讯作者：
Paulk, Angelique C.
影响因子：
5.3
作者：
Burke, John F.;Sharan, Ashwini D.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.
影响因子：
3.9
作者：
Ezzyat, Youssef;Rizzuto, Daniel S.
通讯作者：
Rizzuto, Daniel S.