Exploiting metamerism to regulate the impact of a visual display on alertness and melatonin suppression independent of visual appearance.
Exploiting metamerism to regulate the impact of a visual display on alertness and melatonin suppression independent of visual appearance.
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DOI：
10.1093/sleep/zsy100
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发表时间：
2018-08-01
期刊：
影响因子：
5.6
通讯作者：
Lucas RJ
中科院分区：
文献类型：
--
作者：
Allen AE;Hazelhoff EM;Martial FP;Cajochen C;Lucas RJ
人造光源如视觉显示单元（vdu）引起一系列潜意识和反射的光反应，包括警觉性的增加和松果体褪黑素的抑制。这种反应利用了包含黑视素光感受器的专用视网膜回路。在这里，我们的目的是确定这种安排是否可以在不改变视觉外观的情况下调节vdu对褪黑激素发作和警觉性的影响。我们生成了一个五primary VDU，能够呈现异聚电影（颜色和亮度相匹配），但在黑变辐照度上有所不同。在随机交叉设计中，健康人类参与者（n = 11）于18:00至23:00在高或低黑视设置下暴露于VDU，并每隔30分钟测量唾液褪黑素和自我报告的嗜睡。我们的VDU对颜色和亮度匹配的图像进行了3倍的黑变辐照度调整。参与者报告在不同条件下的视觉外观（颜色和眩光）没有显著差异。在观看VDU的时间里，自我报告的困倦和唾液褪黑素水平显著增加，正如在昼夜周期的这一阶段所预期的那样。当黑变辐照度降低时，这两个参数的增加幅度显著增强。我们的数据表明，在常见的光照情况下（晚上使用VDU），褪黑激素的发作和自我报告的嗜睡可以独立于光度参数（颜色和亮度）进行调节。他们首次证明了光对警觉性和褪黑素产生的影响可以独立于视觉体验进行控制，并建立了能够实现这一目标的VDU。
Artificial light sources such as visual display units (VDUs) elicit a range of subconscious and reflex light responses, including increases in alertness and suppression of pineal melatonin. Such responses employ dedicated retinal circuits encompassing melanopsin photoreceptors. Here, we aimed to determine whether this arrangement can be exploited to modulate the impact of VDUs on melatonin onset and alertness without altering visual appearance. We generated a five-primary VDU capable of presenting metameric movies (matched for color and luminance) but varying in melanopic-irradiance. Healthy human participants (n = 11) were exposed to the VDU from 18:00 to 23:00 hours at high- or low-melanopic setting in a randomized cross-over design and measured salivary melatonin and self-reported sleepiness at 30-minute intervals. Our VDU presented a 3× adjustment in melanopic-irradiance for images matched photometrically for color and luminance. Participants reported no significant difference in visual appearance (color and glare) between conditions. During the time in which the VDU was viewed, self-reported sleepiness and salivary melatonin levels increased significantly, as would be expected in this phase of the diurnal cycle. The magnitude of the increase in both parameters was significantly enhanced when melanopic-irradiance was reduced. Our data demonstrate that melatonin onset and self-reported sleepiness can be modulated independent of photometric parameters (color and luminance) under a commonly encountered light exposure scenario (evening use of a VDU). They provide the first demonstration that the impact of light on alertness and melatonin production can be controlled independently of visual experience, and establish a VDU capable of achieving this objective.
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影响因子：
5.2
作者：
Gringras, Paul;Middleton, Benita;Revell, Victoria L.
通讯作者：
Revell, Victoria L.
DOI：
10.1523/jneurosci.4132-11.2011
发表时间：
2011-11-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Schmidt TM;Do MT;Dacey D;Lucas R;Hattar S;Matynia A
通讯作者：
Matynia A
影响因子：
33.6
作者：
Do MT;Yau KW
通讯作者：
Yau KW
影响因子：
10.3
作者：
Brainard, George C.;Hanifin, John P.;Rollag, Mark
通讯作者：
Rollag, Mark
影响因子：
2.8
作者：
Green, A.;Cohen-Zion, M.;Dagan, Y.
通讯作者：
Dagan, Y.