The hippocampus as the switchboard between perception and memory.
The hippocampus as the switchboard between perception and memory.
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DOI：
10.1073/pnas.2114171118
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发表时间：
2021-12-14
影响因子：
11.1
通讯作者：
Staresina BP
中科院分区：
文献类型：
--
作者：
Treder MS;Charest I;Michelmann S;Martín-Buro MC;Roux F;Carceller-Benito F;Ugalde-Canitrot A;Rollings DT;Sawlani V;Chelvarajah R;Wimber M;Hanslmayr S;Staresina BP
我们如何从感知外部世界适应性地切换到检索与目标相关的内部记忆？为了解决这个问题，我们使用了线索回忆模式，从人类海马体的直接颅内记录，辅以高密度头皮脑电图（EEG）。我们发现，在感知提示后500 ms的海马信号标志着从外部（感知）到内部（记忆）表征的转换。这就启动了一个涉及后顶叶和内侧前额叶皮层的回忆级联反应，通过源定位和时间分辨的EEG α功率来揭示。总之，这些结果揭示了支持快速灵活记忆回忆的大脑皮层动力学。适应性记忆回忆需要从外部感知提醒到内部记忆表征的快速灵活切换。然而，由于有限的时间或空间分辨率的大脑成像模式孤立使用，支持这一过程的大脑皮层动力学仍然未知。因此，我们采用了两项研究，包括颅内脑电图（iEEG）和高密度头皮EEG的对象场景线索回忆范式。首先，持续增加海马高伽玛功率（55至110赫兹）出现后500毫秒的线索开始和区分成功与不成功的回忆。成功回忆的伽马功率增加之后是海马α功率（8至12 Hz）的降低。有趣的是，海马γ功率的增加标志着海马外激活模式从感知线索转向记忆目标表征的时刻。与此同时，源定位EEG阿尔法功率显示，回忆信号从海马到后顶叶皮层，然后到内侧前额叶皮层。总之，这些结果确定了海马作为感知和记忆之间的交换机，并阐明了随后的支持回忆过程的海马皮质动力学。
How do we adaptively switch from perceiving the external world to retrieving goal-relevant internal memories? To tackle this question, we used—in a cued-recall paradigm—direct intracranial recordings from the human hippocampus complemented by high-density scalp electroencephalography (EEG). We found that a hippocampal signal ∼500 ms after a perceptual cue marks the conversion from external (perceptual) to internal (mnemonic) representations. This sets in motion a recall cascade involving posterior parietal and medial prefrontal cortex, revealed via source-localized and time-resolved EEG alpha power. Together, these results unveil the hippocampal–cortical dynamics supporting rapid and flexible memory recall. Adaptive memory recall requires a rapid and flexible switch from external perceptual reminders to internal mnemonic representations. However, owing to the limited temporal or spatial resolution of brain imaging modalities used in isolation, the hippocampal–cortical dynamics supporting this process remain unknown. We thus employed an object-scene cued recall paradigm across two studies, including intracranial electroencephalography (iEEG) and high-density scalp EEG. First, a sustained increase in hippocampal high gamma power (55 to 110 Hz) emerged 500 ms after cue onset and distinguished successful vs. unsuccessful recall. This increase in gamma power for successful recall was followed by a decrease in hippocampal alpha power (8 to 12 Hz). Intriguingly, the hippocampal gamma power increase marked the moment at which extrahippocampal activation patterns shifted from perceptual cue toward mnemonic target representations. In parallel, source-localized EEG alpha power revealed that the recall signal progresses from hippocampus to posterior parietal cortex and then to medial prefrontal cortex. Together, these results identify the hippocampus as the switchboard between perception and memory and elucidate the ensuing hippocampal–cortical dynamics supporting the recall process.
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影响因子：
16.6
作者：
Horner AJ;Bisby JA;Bush D;Lin WJ;Burgess N
通讯作者：
Burgess N
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
16.6
作者：
Ferguson, Michael A.;Lim, Chun;Fox, Michael D.
通讯作者：
Fox, Michael D.
影响因子：
5.3
作者：
Burke, John F.;Sharan, Ashwini D.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.
影响因子：
3.7
作者：
Kiesel, Andrea;Miller, Jeff;Brisson, Benoit
通讯作者：
Brisson, Benoit