Bioinformatics education--perspectives and challenges out of Africa.
Bioinformatics education--perspectives and challenges out of Africa.
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DOI：
10.1093/bib/bbu022
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发表时间：
2015-03
影响因子：
9.5
通讯作者：
H3Africa Consortium
中科院分区：
文献类型：
--
作者：
Tastan Bishop Ö;Adebiyi EF;Alzohairy AM;Everett D;Ghedira K;Ghouila A;Kumuthini J;Mulder NJ;Panji S;Patterton HG;H3ABioNet Consortium;H3Africa Consortium
生物信息学学科自20世纪90年代第一批基因组测序完成以来发展迅速。在过去的几十年中，许多高通量技术的发展确保了生物信息学已经发展成为一门与生命科学中几乎每个领域的现代实践重叠并需要的学科。这使得科学界非常重视熟练的生物信息学家，而这种资格在非洲大陆极为稀缺。造成这种情况的原因很多，但学术机构缺乏熟练的生物信息学家来启动培训进程和建立持续能力似乎是非洲的一个共同缺点。生物信息学专业知识的缺乏对非洲研究所建立许多现代高通量项目产生了连锁反应，包括对非洲人口的基因组进行全面和系统的分析，非洲人口是地球上遗传多样性最丰富的人口之一。美国国立卫生研究院和威康信托基金会最近的资助计划旨在改善这一缺陷。在本文中，我们讨论了限制在非洲建立生物信息学领域的问题，并提出了具体的行动，这将有助于非洲大陆的生物信息学家的教育和培训。这是一个绝对的要求，因为预计非洲人口数据所特有的人类健康问题的高通量方法将蓬勃发展。
The discipline of bioinformatics has developed rapidly since the complete sequencing of the first genomes in the 1990s. The development of many high-throughput techniques during the last decades has ensured that bioinformatics has grown into a discipline that overlaps with, and is required for, the modern practice of virtually every field in the life sciences. This has placed a scientific premium on the availability of skilled bioinformaticians, a qualification that is extremely scarce on the African continent. The reasons for this are numerous, although the absence of a skilled bioinformatician at academic institutions to initiate a training process and build sustained capacity seems to be a common African shortcoming. This dearth of bioinformatics expertise has had a knock-on effect on the establishment of many modern high-throughput projects at African institutes, including the comprehensive and systematic analysis of genomes from African populations, which are among the most genetically diverse anywhere on the planet. Recent funding initiatives from the National Institutes of Health and the Wellcome Trust are aimed at ameliorating this shortcoming. In this paper, we discuss the problems that have limited the establishment of the bioinformatics field in Africa, as well as propose specific actions that will help with the education and training of bioinformaticians on the continent. This is an absolute requirement in anticipation of a boom in high-throughput approaches to human health issues unique to data from African populations.
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影响因子：
56.9
作者：
FLEISCHMANN, RD;ADAMS, MD;VENTER, JC
通讯作者：
VENTER, JC
影响因子：
2
作者：
DAYHOFF, MO
通讯作者：
DAYHOFF, MO
生命科学家的生物信息学培训中的最佳实践。
影响因子：
9.5
作者：
Via A;Blicher T;Bongcam-Rudloff E;Brazas MD;Brooksbank C;Budd A;De Las Rivas J;Dreyer J;Fernandes PL;van Gelder C;Jacob J;Jimenez RC;Loveland J;Moran F;Mulder N;Nyrönen T;Rother K;Schneider MV;Attwood TK
通讯作者：
Attwood TK
影响因子：
8.6
作者：
Moore, Joi L.;Dickson-Deane, Camille;Galyen, Krista
通讯作者：
Galyen, Krista
影响因子：
7.4
作者：
Ruiz, JG;Mintzer, MJ;Leipzig, RM
通讯作者：
Leipzig, RM