Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle.
Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle.
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DOI：
10.3390/vaccines9060621
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发表时间：
2021-06-08
期刊：
影响因子：
7.8
通讯作者：
Elharrak M
中科院分区：
文献类型：
--
作者：
Bamouh Z;Hamdi J;Fellahi S;Khayi S;Jazouli M;Tadlaoui KO;Fihri OF;Tuppurainen E;Elharrak M
瘤状皮肤病病毒（LSDV）在牛中引起一种重要的经济疾病。成功控制的唯一方法是早期诊断和有效的疫苗接种。接种疫苗的不良反应，如注射部位的局部炎症和一些接种过活疫苗的动物的局部或全身性皮肤病变，已被报道。本研究的目的是比较肯尼亚绵羊和山羊痘（KSGP O-240）和LSDV刺痛（Nt）两种瘤状皮肤病（LSD）疫苗株的安全性，并确定在牛中观察到的接种后（pv）反应的病因。实验牛在控制条件下接种Nt-和KSGP o -240疫苗，使用两种不同剂量，观察动物3个月是否有任何不良反应。接种LSDV Nt株的45头牛中有3头（6.7%）和接种Kn株的24头牛中有3头（12.5%）出现lsd样皮肤结节，这表明接种后病变可能不是菌株依赖的。疫苗接种后1-3周出现病变，局限于颈部或覆盖全身。动物在3周后恢复。在接种疫苗的动物中，疫苗剂量与皮肤病变的出现呈正相关；105剂量下，12%的动物反应，而104剂量下为3.7%。在中和抗体血清转化检测保护作用时，两株菌株均产生固体免疫。
Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. The only method for successful control is early diagnosis and efficient vaccination. Adverse effects of vaccination such as local inflammation at the injection site and localized or generalized skin lesions in some vaccinated animals have been reported with live vaccines. The aim of this work was to compare the safety of two lumpy skin disease (LSD) vaccine strains, Kenyan (Kn) Sheep and Goat Pox (KSGP O-240) and LSDV Neethling (Nt) strain, and to determine the etiology of the post-vaccination (pv) reactions observed in cattle. Experimental cattle were vaccinated under controlled conditions with Nt- and KSGP O-240-based vaccines, using two different doses, and animals were observed for 3 months for any adverse reactions. Three out of 45 cattle vaccinated with LSDV Nt strain (6.7%) and three out of 24 cattle vaccinated with Kn strain (12.5%) presented LSD-like skin nodules, providing evidence that the post-vaccination lesions may not be strain-dependent. Lesions appeared 1–3 weeks after vaccination and were localized in the neck or covering the whole body. Animals recovered after 3 weeks. There is a positive correlation between the vaccine dose and the appearance of skin lesions in vaccinated animals; at the 105 dose, 12% of the animals reacted versus 3.7% at the 104 dose. Both strains induced solid immunity when protection was measured by neutralizing antibody seroconversion.
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