Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats.
Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats.
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DOI：
10.1016/j.bbalip.2008.11.002
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发表时间：
2009-02
影响因子：
4.8
通讯作者：
Rapoport, Stanley I.
中科院分区：
文献类型：
--
作者：
Igarashi, Miki;Gao, Fei;Kim, Hyung-Wook;Ma, Kaizong;Bell, Jane M.;Rapoport, Stanley I.
Few studies have examined effects of feeding animals a diet deficient in n-6 polyunsaturated fatty acids (PUFAs) but with an adequate amount of n-3 PUFAs. To do this, we fed post-weaning male rats a control n-6 and n-3 PUFA adequate diet and an n-6 deficient diet for 15 weeks, and measured stable lipid and fatty acid concentrations in different organs. The deficient diet contained nutritionally essential linoleic acid (LA,18:2n-6) as 2.3% of total fatty acids (10% of the recommended minimum LA requirement for rodents) but no arachidonic acid (AA, 20:4n-6), and an adequate amount (4.8% of total fatty acids) of α-linolenic acid (18:3n-3). The deficient compared with adequate diet did not significantly affect body weight, but decreased testis weight by 10%. AA concentration was decreased significantly in serum (−86%), brain (−27%), liver (−68%), heart (−39%), testis (−25%), and epididymal adipose tissue (−77%). Eicosapentaenoic (20:5n-3) and docosahexaenoic acid (22:6n-3) concentrations were increased in all but adipose tissue, and the total monounsaturated fatty acid concentration was increased in all organs. The concentration of 20:3n-9, a marker of LA deficiency, was increased by the deficient diet, and serum concentrations of triacylglycerol, total cholesterol and total phospholipid were reduced. In summary, 15 weeks of dietary n-6 PUFA deficiency with n-3 PUFA adequacy significantly reduced n-6 PUFA concentrations in different organs of male rats, while increasing n-3 PUFA and monounsaturated fatty acid concentrations. This rat model could be used to study metabolic, functional and behavioral effects of dietary n-6 PUFA deficiency.
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影响因子：
4.2
作者：
BOURRE, JM;DURAND, G;YOUYOU, A
通讯作者：
YOUYOU, A
影响因子：
4.2
作者：
BOURRE, JM;FRANCOIS, M;DURAND, G
通讯作者：
DURAND, G
影响因子：
10.6
作者：
HORROBIN, DF;MANKU, MS;GLEN, M
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GLEN, M
影响因子：
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作者：
Bazinet, RP;Douglas, H;Cunnane, SC
通讯作者：
Cunnane, SC
DOI：
10.1097/mco.0b013e32802b7030
发表时间：
2007-03-01
影响因子：
3.1
作者：
Bazan, Nicolas G.
通讯作者：
Bazan, Nicolas G.