Grip Strength Trajectories and Cognition in English and Chilean Older Adults: A Cross-Cohort Study.
Grip Strength Trajectories and Cognition in English and Chilean Older Adults: A Cross-Cohort Study.
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DOI：
10.3390/jpm12081230
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发表时间：
2022-07-27
影响因子：
--
通讯作者：
Bendayan, Rebecca
中科院分区：
文献类型：
--
作者：
Angel, Barbara;Ajnakina, Olesya;Albala, Cecilia;Lera, Lydia;Marquez, Carlos;Leipold, Leona;Bilovich, Avri;Dobson, Richard;Bendayan, Rebecca
越来越多的证据表明，认知能力下降和身体机能衰退之间的联系表明，身体机能的早期变化是认知障碍的潜在生物标记物。因此，我们比较了两个具有代表性的英国和智利老年人样本中，根据认知状态(两种稳定模式，正常和认知能力受损，以及下降模式)分类的三组12-16年间的握力轨迹。样本包括7069名英国(Elsa)和1363名智利参与者(Alexandros)。采用线性混合模型。调整包括社会人口统计和健康变量。与非受损组相比，下降组和受损组在基线时握力显著降低。在ELSA中，下降和受损的人与非受损的人相比，他们的握力下降得更快，但在完全调整的模型中差异消失了。在Alexandros，这种差异只在衰退者和非受损者之间发现，并且它们被协变量部分减弱。我们的研究提供了强有力的证据，证明了握力和认知能力之间的联系，以及社会经济因素如何可能是理解这种联系及其在不同国家之间差异的关键。这对未来的流行病学研究具有重要意义，因为握力测量有可能被用作认知能力的指标。
Growing evidence about the link between cognitive and physical decline suggests the early changes in physical functioning as a potential biomarker for cognitive impairment. Thus, we compared grip-strength trajectories over 12–16 years in three groups classified according to their cognitive status (two stable patterns, normal and impaired cognitive performance, and a declining pattern) in two representative UK and Chilean older adult samples. The samples consisted of 7069 UK (ELSA) and 1363 Chilean participants (ALEXANDROS). Linear Mixed models were performed. Adjustments included socio-demographics and health variables. The Declined and Impaired group had significantly lower grip-strength at baseline when compared to the Non-Impaired. In ELSA, the Declined and Impaired showed a faster decline in their grip strength compared to the Non-Impaired group but differences disappeared in the fully adjusted models. In ALEXANDROS, the differences were only found between the Declined and Non-Impaired and they were partially attenuated by covariates. Our study provides robust evidence of the association between grip strength and cognitive performance and how socio-economic factors might be key to understanding this association and their variability across countries. This has implications for future epidemiological research, as hand-grip strength measurements have the potential to be used as an indicator of cognitive performance.
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影响因子：
3.5
作者：
Christensen, H;Korten, AE;Rodgers, B
通讯作者：
Rodgers, B
影响因子：
5.8
作者：
Gallucci, M.;Mazzuco, S.;Regini, C.
通讯作者：
Regini, C.
影响因子：
1.9
作者：
Farina, Nicolas;Tabet, Naji;Rusted, Jennifer
通讯作者：
Rusted, Jennifer
影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM
影响因子：
5.7
作者：
Buchman, Aron S.;Wilson, Robert S.;Bennett, David A.
通讯作者：
Bennett, David A.