Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility

Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility
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表面引发ATRP从聚砜膜上接枝两性离子,增强防污性能和生物相容性

DOI:
10.1016/j.memsci.2013.06.029
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发表时间:
2013-11
影响因子:
9.5
通讯作者:
Zhao, Chang-Sheng
Zhao, Chang-Sheng
中科院分区:
工程技术1区
文献类型:
--
作者:
Xiang, Tao;Qin, Hui;Sun, Shu-Dong;Zhao, Chang-Sheng

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采用原子转移自由基聚合法(SI-ATRP),在聚砜(PSf)膜上接枝了聚甲基丙烯酸磺基甜菜碱(PSBMA)两性离子聚合物。采用扫描电子显微镜(SEM)、原子力显微镜(AFM)、衰减全反射-傅里叶变换红外光谱(ATR-FTIR)、X射线光电子能谱(XPS)和静态水接触角(WCA)等方法对聚砜接枝聚甲基丙烯酸磺基甜菜碱(PSf-g-PSBMA)膜进行了表征。改性后的膜在水通量有所下降的情况下仍具有良好的蛋白质截留性能,但蛋白质截留率基本不变。通过蛋白质吸附、溶血试验、血小板粘附、血浆凝固时间、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和细胞毒性试验对膜的生物相容性进行了表征,结果表明,改性聚砜膜具有良好的血液相容性和细胞相容性。
Zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA) was grafted from polysulfone (PSf) membraneviasurface-initiated atom transfer radical polymerization (SI-ATRP). The polysulfone-graft-poly(sulfobetaine methacrylate) (PSf-g-PSBMA) membrane was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflectance-Fourier transform infrared spectra (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and static water contact angle (WCA) measurement. The membrane showed excellent protein antifouling property though the water flux decreased to some content; nevertheless, the protein rejection ratio of the modified membrane was not change. The biocompatibility of the membrane was characterized by protein adsorption, hemolysis assay, platelet adhesion, plasma recalcification time, activated partial thromboplastin time (APTT), thrombin time (TT) and cytotoxicity experiments, and the results indicated that the modified PSf membrane had good blood compatibility and cytocompatibility.
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