Placenta microstructure and microcirculation imaging with diffusion MRI.
Placenta microstructure and microcirculation imaging with diffusion MRI.
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DOI：
10.1002/mrm.27036
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发表时间：
2018-08
影响因子：
3.3
通讯作者：
Alexander DC
中科院分区：
文献类型：
--
作者：
Slator PJ;Hutter J;McCabe L;Gomes ADS;Price AN;Panagiotaki E;Rutherford MA;Hajnal JV;Alexander DC
评估哪种微观结构模型最能解释人类胎盘中的扩散加权 MRI 信号。使用多壳、多向扩散方案以 3T 扫描 9 名健康怀孕受试者的胎盘。一系列多室生物物理模型适合数据，并使用贝叶斯信息标准进行排序。体素内不相干运动模型的各向异性扩展考虑了微血管结构和组织微结构中相干方向的影响，始终具有最低的贝叶斯信息准则值。模型参数图和模型选择结果与胎盘及周围组织的生理情况一致。使用此协议时，各向异性体素内不相干运动模型比表观扩散系数、体素内不相干运动和扩散张量模型更好地解释胎盘扩散信号。未来的工作将旨在确定模型衍生的参数是否对与胎儿生长受限和早发先兆子痫等疾病相关的胎盘病理敏感。 Magn Reson Med 80:756–766, 2018。© 2017 The Authors Magnetic Resonance in Medicine 由 Wiley periodicals, Inc. 代表国际医学磁共振学会出版。这是一篇根据知识共享署名许可条款的开放获取文章，允许在任何媒体上使用、分发和复制，前提是正确引用了原始作品。
To assess which microstructural models best explain the diffusion‐weighted MRI signal in the human placenta. The placentas of nine healthy pregnant subjects were scanned with a multishell, multidirectional diffusion protocol at 3T. A range of multicompartment biophysical models were fit to the data, and ranked using the Bayesian information criterion. Anisotropic extensions to the intravoxel incoherent motion model, which consider the effect of coherent orientation in both microvascular structure and tissue microstructure, consistently had the lowest Bayesian information criterion values. Model parameter maps and model selection results were consistent with the physiology of the placenta and surrounding tissue. Anisotropic intravoxel incoherent motion models explain the placental diffusion signal better than apparent diffusion coefficient, intravoxel incoherent motion, and diffusion tensor models, in information theoretic terms, when using this protocol. Future work will aim to determine if model‐derived parameters are sensitive to placental pathologies associated with disorders, such as fetal growth restriction and early‐onset pre‐eclampsia. Magn Reson Med 80:756–766, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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影响因子：
3.3
作者：
Hutter, Jana;Price, Anthony N.;Hajnal, Joseph V.
通讯作者：
Hajnal, Joseph V.
影响因子：
3.3
作者：
Frias, Antonio E.;Schabel, Matthias C.;Roberts, Victoria H. J.;Tudorica, Alina;Grigsby, Peta L.;Oh, Karen Y.;Kroenke, Christopher D.
通讯作者：
Kroenke, Christopher D.
影响因子：
6.1
作者：
Kam, EPY;Gardner, L;King, A
通讯作者：
King, A
影响因子：
4.4
作者：
Guyader, Jean-Marie;Bernardin, Livia;Klein, Stefan
通讯作者：
Klein, Stefan
影响因子：
19.7
作者：
LEBIHAN, D;BRETON, E;LAVALJEANTET, M
通讯作者：
LAVALJEANTET, M