Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity.
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity.
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DOI：
10.1016/j.physbeh.2013.03.025
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发表时间：
2013-09-10
影响因子：
2.9
通讯作者：
Small DM
中科院分区：
文献类型：
--
作者：
Babbs RK;Sun X;Felsted J;Chouinard-Decorte F;Veldhuizen MG;Small DM
以前的研究一致报告，在食用可口和能量密集的食物期间，体重指数（BMI）和尾状核的反应之间存在负相关。由于这种反应也与体重增加有关，我们试图复制这一发现，并确定反应降低是否与冲动或食物奖励有关。在两项研究中，fMRI被用来测量大脑对奶昔和无味对照溶液的反应。在研究1（n = 25）中，我们还评估了自我报告的冲动性，为食物工作的意愿，以及对奶昔味道和香味的愉悦感的主观体验。重复以前的工作，我们报告了体重指数和大脑对奶昔的反应与尾状核无味之间的负相关。在腹侧壳核中观察到相反的模式，与12名健康体重受试者相比，在13名超重受试者中观察到更大的反应。对冲动性和食物奖励措施的大脑反应回归揭示了一个显着的关联：在超重但不健康的体重组中，自我报告的冲动性与尾状核对奶昔的反应呈负相关。在研究2（n = 14）中，除了评估大脑对奶昔和无味溶液的反应外，受试者还在扫描仪外完成了去/不去任务。正如预测的那样，我们确定了尾状核对奶昔的反应与无味之间的反比关系，以及在不进行试验中抑制反应的失败。我们的结论是，体重指数和尾状核对奶昔的反应之间的负相关与冲动有关，但与食物奖励无关。这些发现表明，背侧纹状体对奶昔的反应可能通过促进冲动性进食行为而与体重增加有关。
Previous investigations consistently report a negative association between body mass index (BMI) and response in the caudate nucleus during the consumption of palatable and energy dense food. Since this response has also been linked to weight gain, we sought to replicate this finding and determine if the reduced response is associated with measures of impulsivity or food reward. Two studies were conducted in which fMRI was used to measure brain response to milkshake and a tasteless control solution. In study 1 (n = 25) we also assessed self-reported impulsivity, willingness to work for food, and subjective experiences of the pleasantness of milkshake taste and aroma. Replicating prior work, we report a negative association between BMI and brain response to milkshake vs. tasteless in the caudate nucleus. The opposite pattern was observed in the ventral putamen, with greater response observed in the 13 overweight compared to the 12 healthy weight subjects. Regression of brain response against impulsivity and food reward measures revealed one significant association: in the overweight but not healthy weight group self-reported impulsivity was negatively associated with caudate response to milkshake. In study 2 (n = 14), in addition to assessing brain response to milkshake and tasteless solutions subjects completed a go/no-go task outside the scanner. As predicted, we identified an inverse relationship between caudate response to milkshake vs. tasteless and failure to inhibit responses on the no go trials. We conclude that the inverse correlation between BMI and caudate response to milkshake is associated with impulsivity but not food reward. These findings suggest that response to milkshake in the dorsal striatum may be related to weight gain by promoting impulsive eating behavior.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
2.9
作者：
Green E;Jacobson A;Haase L;Murphy C
通讯作者：
Murphy C
影响因子：
11
作者：
Jönsson, EG;Nöthen, MM;Sedvall, GC
通讯作者：
Sedvall, GC
影响因子：
5.4
作者：
Davis, C;Strachan, S;Berkson, M
通讯作者：
Berkson, M
3至12岁的儿童的自我调节和体重快速增加。
影响因子：
--
作者：
Francis, Lori A.;Susman, Elizabeth J.
通讯作者：
Susman, Elizabeth J.