Mismatch negativity of sad syllables is absent in patients with major depressive disorder.
Mismatch negativity of sad syllables is absent in patients with major depressive disorder.
复制标题
DOI：
10.1371/journal.pone.0091995
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Pang X;Xu J;Chang Y;Tang D;Zheng Y;Liu Y;Sun Y
严重抑郁障碍(MDD)是一种重要的、高度流行的精神障碍，其特征是缺乏快感和对日常活动缺乏兴趣。此外，MDD患者似乎在各种认知能力方面存在缺陷。尽管一些研究MDD患者低水平声音特征的中枢听觉加工已经证明这一群体在自动加工方面存在障碍，但情绪语音加工的影响尚未得到解决。为了探索MDD患者情绪韵律的自动处理，我们分析了使用事件相关电位(ERPs)检测自动变化的能力。这项研究包括18名MDD患者和22名年龄和性别匹配的健康对照。受试者被指示观看无声电影，但忽略呈现给两只耳朵的传入声学情感韵律，同时同步记录持续的脑电活动。韵律包括无意义的音节，比如用高兴、愤怒、悲伤或中性的语调说出的“dada”。分析情绪刺激诱发事件相关电位的平均波幅和情绪差分波的峰潜伏期。在MDD患者中没有悲伤的MMN，而快乐和愤怒的MMN成分在不同组之间是相似的。异常悲伤情绪MMN成分与HRSD-17、HAMA评分均无显著相关。数据表明，MDD患者自动处理悲伤韵律的能力受到损害，而他们处理快乐和愤怒韵律的能力保持正常。MDD患者功能障碍的悲伤情绪相关MMN与抑郁症状无相关性。悲伤韵律的迟钝MMN可以被认为是MDD的特征。
Major depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigating the central auditory processing of low-level sound features in patients with MDD have demonstrated that this population exhibits impairments in automatic processing, the influence of emotional voice processing has yet to be addressed. To explore the automatic processing of emotional prosodies in patients with MDD, we analyzed the ability to detect automatic changes using event-related potentials (ERPs). This study included 18 patients with MDD and 22 age- and sex-matched healthy controls. Subjects were instructed to watch a silent movie but to ignore the afferent acoustic emotional prosodies presented to both ears while continuous electroencephalographic activity was synchronously recorded. Prosodies included meaningless syllables, such as “dada” spoken with happy, angry, sad, or neutral tones. The mean amplitudes of the ERPs elicited by emotional stimuli and the peak latency of the emotional differential waveforms were analyzed. The sad MMN was absent in patients with MDD, whereas the happy and angry MMN components were similar across groups. The abnormal sad emotional MMN component was not significantly correlated with the HRSD-17 and HAMA scores, respectively. The data indicate that patients with MDD are impaired in their ability to automatically process sad prosody, whereas their ability to process happy and angry prosodies remains normal. The dysfunctional sad emotion-related MMN in patients with MDD were not correlated with depression symptoms. The blunted MMN of sad prosodies could be considered a trait of MDD.
登录
查看更多内容
影响因子：
4.7
作者：
Jacobsen, T;Schröger, E
通讯作者：
Schröger, E
影响因子：
2.4
作者：
Basso, MR;Bornstein, RA
通讯作者：
Bornstein, RA
影响因子：
4.7
作者：
Lepistö, T;Soininen, M;Aronen, ET
通讯作者：
Aronen, ET
影响因子：
11.3
作者：
Bearden, Carrie E.;Glahn, David C.;Soares, Jair C.
通讯作者：
Soares, Jair C.
影响因子：
3.4
作者：
Leung, Sumie;Croft, Rodney J.;Nathan, Pradeep J.
通讯作者：
Nathan, Pradeep J.