Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial.
Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial.
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使用斜偏振反射光谱探测口腔局部组织变化以早期检测癌症：一项试点临床试验。
DOI：
10.1117/1.2907450
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发表时间：
2008
影响因子：
3.5
通讯作者：
Sokolov,Konstantin
中科院分区：
文献类型：
--
作者：
Nieman,LindaT;Kan,Chih-Wen;Gillenwater,Ann;Markey,MiaK;Sokolov,Konstantin
我们报告了一项口腔试点临床试验的结果，该试验使用斜向收集纤维的光纤探针检测早期癌前病变和癌症，该探针优先探测局部组织形态和异质性，使用斜偏振反射光谱（OPRS）。我们提取上皮细胞的细胞核大小和10个光谱特征。这些特征是独立分析和组合，以评估诊断类分离的最佳指标。在没有根据解剖位置或角化程度对数据进行分层的情况下，OPRS被发现对四种诊断类别敏感：正常、良性、轻度不典型增生、高度不典型增生和癌。采用线性判别分析，将正常与高级别非典型增生和癌区分开的敏感性和特异性分别为90%和86%。区分形态相似的病变，如正常和轻度发育不良的敏感性为75%，特异性为73%。视觉上难以区分的良性病变与高级别发育不良和癌的分离具有良好的灵敏度（100%）和特异性（85%），而良性病变与轻度发育不良的分离灵敏度为92%，特异性为69%。这些有希望的结果表明，OPRS有潜力帮助筛查和诊断口腔癌前病变和癌症。
We report the results of an oral cavity pilot clinical trial to detect early precancer and cancer using a fiber optic probe with obliquely oriented collection fibers that preferentially probe local tissue morphology and heterogeneity using oblique polarized reflectance spectroscopy (OPRS). We extract epithelial cell nuclear sizes and 10 spectral features. These features are analyzed independently and in combination to assess the best metrics for separation of diagnostic classes. Without stratifying the data according to anatomical location or level of keratinization, OPRS is found to be sensitive to four diagnostic categories: normal, benign, mild dysplasia, high-grade dysplasia, and carcinoma. Using linear discriminant analysis, separation of normal from high-grade dysplasia and carcinoma yield a sensitivity and specificity of 90 and 86%, respectively. Discrimination of morphologically similar lesions such as normal from mild dysplasia is achieved with a sensitivity of 75% and specificity of 73%. Separation of visually indistinguishable benign lesions from high-grade dysplasia and carcinoma is achieved with good sensitivity (100%) and specificity (85%), while separation of benign from mild dysplasia gives a sensitivity of 92% and a specificity of 69%. These promising results suggest that OPRS has the potential to aid screening and diagnosis of oral precancer and cancer.
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DOI：
10.1002/hed.10381
发表时间：
2004-03-01
影响因子：
2.9
作者：
Svistun, E;Alizadeh-Naderi, R;Richards-Kortum, R
通讯作者：
Richards-Kortum, R
用于体内偏振反射光谱的光纤探头：设计和性能。
影响因子：
3.5
作者：
A. Myakov;Linda T. Nieman;Lorenz Wicky;U. Utzinger;R. Richards;K. Sokolov
通讯作者：
K. Sokolov
影响因子：
1.9
作者：
Michael P. Siegel;Young L. Kim;H. Roy;R. Wali;V. Backman
通讯作者：
Michael P. Siegel;Young L. Kim;H. Roy;R. Wali;V. Backman
影响因子：
9.8
作者：
Georgakoudi, I;Sheets, EE;Feld, MS
通讯作者：
Feld, MS
影响因子：
11.2
作者：
Zhang, LW;Williams, M;Rosin, MP
通讯作者：
Rosin, MP