Maternal modulation of paternal effects on offspring development.
Maternal modulation of paternal effects on offspring development.
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DOI：
10.1098/rspb.2018.0118
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发表时间：
2018-03-14
期刊：
影响因子：
--
通讯作者：
Champagne FA
中科院分区：
文献类型：
--
作者：
Mashoodh R;Habrylo IB;Gudsnuk KM;Pelle G;Champagne FA
据报道，环境诱导表型的父方跨代传播发生在一些性质不同的暴露之后，并且似乎至少部分地由通过精子遗传的表观遗传因素驱动。然而，以前的研究父系生殖系传播没有解决的作用，母亲在传播父亲的影响，以后代。我们假设，父亲暴露于营养限制会影响男性伴侣的质量和随后的母亲生殖投资的后果，父亲的生殖系效应的传输。在目前的报告中，使用小鼠胚胎移植，我们证明了成年食物限制男性的精子因素会影响女性后代的生长速度，下丘脑基因表达和行为。然而，在自然交配条件下，与食物限制的男性交配的女性显示出产前和产后护理的增加，并且在胚胎移植条件下观察到的表型结果不存在或逆转。我们证明，这些补偿性变化，在母体投资与减少食物限制男性和产妇下丘脑内的基因表达升高的配偶偏好。因此，父亲的经验可以影响后代的发展，通过生殖系遗传，但母亲可以作为一个调节因素，在确定父亲的影响对后代的发展。
The paternal transmission of environmentally induced phenotypes across generations has been reported to occur following a number of qualitatively different exposures and appear to be driven, at least in part, by epigenetic factors that are inherited via the sperm. However, previous studies of paternal germline transmission have not addressed the role of mothers in the propagation of paternal effects to offspring. We hypothesized that paternal exposure to nutritional restriction would impact male mate quality and subsequent maternal reproductive investment with consequences for the transmission of paternal germline effects. In the current report, using embryo transfer in mice, we demonstrate that sperm factors in adult food restricted males can influence growth rate, hypothalamic gene expression and behaviour in female offspring. However, under natural mating conditions females mated with food restricted males show increased pre- and postnatal care, and phenotypic outcomes observed during embryo transfer conditions are absent or reversed. We demonstrate that these compensatory changes in maternal investment are associated with a reduced mate preference for food restricted males and elevated gene expression within the maternal hypothalamus. Therefore, paternal experience can influence offspring development via germline inheritance, but mothers can serve as a modulating factor in determining the impact of paternal influences on offspring development.
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DOI：
10.1073/pnas.0610410104
发表时间：
2007-04-03
影响因子：
11.1
作者：
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影响因子：
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