Human milk oligosaccharides and the infant gut microbiome from an eco-evolutionary perspective.
Human milk oligosaccharides and the infant gut microbiome from an eco-evolutionary perspective.
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从生态进化的角度来看人乳低聚糖和婴儿肠道微生物组。
DOI：
10.1016/j.mib.2022.102156
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发表时间：
2022
影响因子：
5.4
通讯作者：
M. Yassour
中科院分区：
文献类型：
--
作者：
Sivan Kijner;O. Kolodny;M. Yassour
母乳寡糖是母乳中发现的独特的复合糖，但婴儿不能消化它们。肠道微生物可以利用HMO，因此，母乳喂养塑造了婴儿的微生物组。社区生态学理论揭示了婴儿肠道的建立过程。进化方法建议母亲投资于HMO生产的策略。母乳寡糖（HMO）是母乳中发现的聚糖家族，具有200多种已鉴定的结构。尽管HMO是母乳中的第三大成分，但婴儿无法消化，这提出了一个有趣的问题：我们希望进化动力学塑造母乳，以有效地满足婴儿的营养需求;那么，HMO的作用是什么呢？追踪它们的命运提供了一个答案：它们被某些肠道细菌代谢，这表明母乳已经被构造成塑造发育中的婴儿微生物组。我们认为，生态学范式，特别是优先效应的概念，可以帮助将HMO作为塑造肠道微生物组的试剂的重要性置于背景中。这一过程的健康结果提供了关于塑造母乳成分的进化力量的见解。在这篇综述中，我们提供了一个生态进化的角度来看，并提出了经验数据相关联的组成母乳和婴儿的肠道微生物。
HighlightsHMOs are unique complex sugars found in breastmilk, however infants can't digest them.Gut microbes can utilize HMOs, thus, breastfeeding shapes the infant microbiome.Community-ecology theories shed light on the establishment process of the infant gut.Evolutionary approaches suggest strategies for maternal investment in HMO production.Human milk oligosaccharides (HMOs) are a family of glycans found in breastmilk with over 200 identified structures. Despite being the third-largest component in breastmilk, HMOs are indigestible by infants, which raises an intriguing question: we would expect evolutionary dynamics to have shaped breastmilk to efficiently fulfill the baby’s nutritional needs; what, then, could be the role of HMOs? Tracking their fate offers an answer: they are metabolized by certain gut bacteria, suggesting that breastmilk has been structured to shape the developing infant microbiome. We suggest that ecological paradigms, in particular, the notion of priority effects, can help contextualize the importance of HMOs as agents shaping the gut microbiome. The fitness consequences of this process provide insight regarding the evolutionary forces that have shaped the composition of breastmilk. In this review, we offer an eco-evolutionary perspective and present empirical data associating the compositions of mothers’ milk and their infants’ gut microbiomes.
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影响因子：
30.3
作者：
Marcobal A;Barboza M;Sonnenburg ED;Pudlo N;Martens EC;Desai P;Lebrilla CB;Weimer BC;Mills DA;German JB;Sonnenburg JL
通讯作者：
Sonnenburg JL
影响因子：
30.3
作者：
Gevers D;Kugathasan S;Denson LA;Vázquez-Baeza Y;Van Treuren W;Ren B;Schwager E;Knights D;Song SJ;Yassour M;Morgan XC;Kostic AD;Luo C;González A;McDonald D;Haberman Y;Walters T;Baker S;Rosh J;Stephens M;Heyman M;Markowitz J;Baldassano R;Griffiths A;Sylvester F;Mack D;Kim S;Crandall W;Hyams J;Huttenhower C;Knight R;Xavier RJ
通讯作者：
Xavier RJ
影响因子：
4.2
作者：
Smilowitz, Jennifer T.;O'Sullivan, Aifric;Supsky, Carolyn M.
通讯作者：
Supsky, Carolyn M.
影响因子：
4.2
作者：
Newburg, DS
通讯作者：
Newburg, DS
影响因子：
8.9
作者：
Smilowitz JT;Lebrilla CB;Mills DA;German JB;Freeman SL
通讯作者：
Freeman SL