Particle-collision and porogen-leaching technique to fabricate polymeric porous scaffolds with microscale roughness of interior surfaces
Particle-collision and porogen-leaching technique to fabricate polymeric porous scaffolds with microscale roughness of interior surfaces
复制标题
粒子碰撞和致孔剂浸出技术制备具有微尺度粗糙内表面的聚合物多孔支架
DOI：
10.1007/s10118-013-1264-1
复制
发表时间：
2013-04
影响因子：
4.3
通讯作者：
ong Ding
中科院分区：
文献类型：
--
作者：
Zheng Zhang;Rong Peng;Ce Yan;Ji;ong Ding
本文报道了一种简便的技术来制造三维（3D）聚合物多孔支架，其内表面具有有利于细胞粘附的地形微结构。作为证明，采用众所周知的可生物降解聚合物聚（丙交酯-共-乙交酯）（PLGA）作为基质。在致孔剂-浸出策略下，大而软的石蜡致孔剂通过与小而硬的盐颗粒碰撞而改性，在石蜡球表面产生微坑。因此，在沥滤改性致孔剂之后，最终的PLGA支架具有由那些微坑压印的微尺度粗糙度的内表面。结果表明，微粗糙支架有利于大鼠骨髓基质细胞（BMSCs）的黏附，同时不影响细胞的增殖和成骨分化。这些观点和技术对组织工程和再生医学领域的生物材料设计具有一定的指导意义。
A facile technique is herein reported to fabricate three-dimensional (3D) polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly(lactide-co-glycolide) (PLGA) was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells (BMSCs) of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.
登录
查看更多内容
影响因子：
14
作者：
Mata, Alvaro;Kim, Eun Jung;Boehm, Cynthia A.;Fleischman, Aaron J.;Muschler, George F.;Roy, Shuvo
通讯作者：
Roy, Shuvo
影响因子：
4
作者：
M. López‐Álvarez;I. Pereiro;J. Serra;A. de Carlos;P. González
通讯作者：
M. López‐Álvarez;I. Pereiro;J. Serra;A. de Carlos;P. González
影响因子：
4.3
作者：
Yijiang Liu;Hongliang Jiang;Y. Li;K. Zhu
通讯作者：
Yijiang Liu;Hongliang Jiang;Y. Li;K. Zhu
影响因子：
14
作者：
Charest, JL;Eliason, MT;King, WP
通讯作者：
King, WP
影响因子：
--
作者：
Ma, PX;Choi, JW
通讯作者：
Choi, JW