Olfactory dysfunction in Parkinson's disease: Positive effect of cigarette smoking.
Olfactory dysfunction in Parkinson's disease: Positive effect of cigarette smoking.
复制标题
DOI：
10.1002/mds.26126
复制
发表时间：
2015-05
影响因子：
8.6
通讯作者：
Doty, Richard L.
中科院分区：
文献类型：
--
作者：
Sharer, James D.;Leon-Sarmiento, Fidias E.;Morley, James F.;Weintraub, Daniel;Doty, Richard L.
来自60多项流行病学研究的令人信服的证据表明，吸烟可显着降低帕金森病（PD）的风险。一般来说，那些目前吸烟的人，以及那些有吸烟史的人，与从未吸烟的人相比，PD的风险降低。最近有人提出，PD的一个主要的非运动感觉症状，嗅觉功能障碍，可能是不那么严重的PD患者吸烟比PD患者不吸烟，在一般人群中描述的吸烟对嗅觉的负面影响。我们评估了来自323名帕金森病患者和323名对照者的宾夕法尼亚大学帕金森病识别测试（UPSIT）评分，这些患者和对照者在年龄、性别和吸烟史（从未、过去和现在）方面非常匹配。患者的UPSIT评分明显低于对照组（P<0.0001）。当前PD吸烟者的功能障碍的相对下降小于从未和过去PD吸烟者的功能障碍的相对下降（分别为P =0.0005和0.0019）。女性PD患者比女性对照组表现出更大的优势（3.66 vs. 1.07 UPSIT点;分别P < 0.0001和0.06）。UPSIT评分普遍存在与血压相关的下降（P < 0.0001）。嗅觉测量和吸烟剂量之间没有明显的关联，以包年为指数。目前吸烟的PD患者没有表现出在目前吸烟的非PD对照受试者中观察到的吸烟相关的嗅觉下降。这一现象的生理基础尚待确定。
There is compelling evidence from over 60 epidemiological studies that smoking significantly reduces the risk of Parkinson’s disease (PD). In general, those who currently smoke cigarettes, as well as those with a past history of such smoking, have a reduced risk of PD compared to those who have never smoked. Recently it has been suggested that a cardinal non-motor sensory symptom of PD, olfactory dysfunction, may be less severe in PD patients who smoke than in PD patients who do not, in contrast to the negative effect of smoking on olfaction described in the general population. We evaluated University of Pennsylvania Smell Identification Test (UPSIT) scores from 323 Parkinson’s patients and 323 controls closely matched individually on age, sex, and smoking history (never, past, current). The patients exhibited much lower UPSIT scores than did the controls (P<0.0001). The relative decline in dysfunction of the current PD smokers was less than that of the never- and past-PD smokers (respective Ps=0.0005 & 0.0019). The female PD patients outperformed their male counterparts by a larger margin than did the female controls (3.66 vs. 1.07 UPSIT points; respective Ps < 0.0001 & 0.06). Age-related declines in UPSIT scores were generally present (P < 0.0001). No association between the olfactory measure and smoking dose, as indexed by pack years, was evident. PD patients who currently smoke do not exhibit the smoking-related decline in olfaction observed in non-PD control subjects who currently smoke. The physiologic basis of this phenomenon is yet to be defined.
登录
查看更多内容
影响因子：
8.6
作者：
Lucassen, Elisabeth B.;Sterling, Nicholas W.;Lee, Eun-Young;Chen, Honglei;Lewis, Mechelle M.;Kong, Lan;Huang, Xuemei
通讯作者：
Huang, Xuemei
影响因子：
4.4
作者：
Moccia, Marcello;Picillo, Marina;Pellecchia, Maria Teresa
通讯作者：
Pellecchia, Maria Teresa
影响因子：
3.8
作者：
Doty RL;Kamath V
通讯作者：
Kamath V
影响因子：
3.8
作者：
DOTY, RL;REYES, PF;GREGOR, T
通讯作者：
GREGOR, T
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M