The effects of electronic cigarette emissions on systemic cotinine levels, weight and postnatal lung growth in neonatal mice.
The effects of electronic cigarette emissions on systemic cotinine levels, weight and postnatal lung growth in neonatal mice.
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DOI：
10.1371/journal.pone.0118344
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
McGrath-Morrow SA;Hayashi M;Aherrera A;Lopez A;Malinina A;Collaco JM;Neptune E;Klein JD;Winickoff JP;Breysse P;Lazarus P;Chen G
电子烟(电子烟)通过吸入、皮肤和口腔接触对新生儿构成潜在的新危害。接触含有尼古丁的电子烟可能会导致新生儿的大量全身吸收，因为可能会有多条途径接触。全身吸收尼古丁和电子烟排放的成分可能会对新生儿的体重和肺发育产生不利影响。为了解决这些问题，我们将新生小鼠暴露在电子烟排放中，并测量了全身可替宁水平和肺泡生长。新生的小鼠在出生后的前10天一直接触电子烟。电子烟盒中含有1.8%的尼古丁在丙二醇(PG)中或仅在PG车辆中。用肺泡平均线性截距(MLI)法测量出生10天时的每日体重、血浆和尿可替宁水平以及肺生长，并与室内空气对照进行比较。与室内空气对照组相比，暴露于1.8%尼古丁/PG的小鼠的总体重减少了13.3%。暴露于1.8%尼古丁/PG电子烟的新生小鼠血浆可替宁水平升高(平均为62.34±3.3 ng/ml)。在调整了性别和体重后，MLI发现接触尼古丁的小鼠与室内空气对照组的小鼠相比，肺部生长受到了轻微的损害(P<；.054试验1；p<；.006试验2)。这些研究表明，在新生儿期接触电子烟排放会对体重增加产生不利影响。此外，暴露在含有尼古丁的电子烟中会导致可检测到的全身可替宁水平，降低肺泡细胞增殖，并对出生后肺生长造成轻微损害。
Electronic cigarette (E-cigarettes) emissions present a potentially new hazard to neonates through inhalation, dermal and oral contact. Exposure to nicotine containing E-cigarettes may cause significant systemic absorption in neonates due to the potential for multi-route exposure. Systemic absorption of nicotine and constituents of E-cigarette emissions may adversely impact weight and lung development in the neonate. To address these questions we exposed neonatal mice to E-cigarette emissions and measured systemic cotinine levels and alveolar lung growth. Neonatal mice were exposed to E-cigarettes for the first 10 days of life. E-cigarette cartridges contained either 1.8% nicotine in propylene glycol (PG) or PG vehicle alone. Daily weights, plasma and urine cotinine levels and lung growth using the alveolar mean linear intercept (MLI) method were measured at 10 days of life and compared to room air controls. Mice exposed to 1.8% nicotine/PG had a 13.3% decrease in total body weight compared to room air controls. Plasma cotinine levels were found to be elevated in neonatal mice exposed to 1.8% nicotine/PG E-cigarettes (mean 62.34± 3.3 ng/ml). After adjusting for sex and weight, the nicotine exposed mice were found to have modestly impaired lung growth by MLI compared to room air control mice (p<.054 trial 1; p<.006 trial 2). These studies indicate that exposure to E-cigarette emissions during the neonatal period can adversely impact weight gain. In addition exposure to nicotine containing E-cigarettes can cause detectable levels of systemic cotinine, diminished alveolar cell proliferation and a modest impairment in postnatal lung growth.
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