Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.
Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.
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DOI：
10.1038/s41593-023-01296-6
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发表时间：
2023-05
影响因子：
25
通讯作者：
Kheirbek, Mazen A.
中科院分区：
文献类型：
--
作者：
Biane, Jeremy S.;Ladow, Max A.;Stefanini, Fabio;Boddu, Sayi P.;Fan, Austin;Hassan, Shazreh;Dundar, Naz;Apodaca-Montano, Daniel L.;Zhou, Lexi Zichen;Fayner, Varya;Woods, Nicholas I.;Kheirbek, Mazen A.
动物将线索与结果联系起来，并随着新信息的出现而更新这些联系。这需要海马体，然而海马神经元如何跟踪线索-结果关联的变化仍不清楚。使用双光子钙成像，我们跟踪了相同的dCA1和vCA1神经元数天，以确定反应如何在气味结果学习的不同阶段演变。最初，气味在dCA1中引发强烈的反应，而在vCA1中，气味反应主要出现在学习和嵌入关于配对结果的信息之后。这两个区域的种群活动随着学习而迅速重组，然后稳定下来，即使在物种灭绝或与不同结果配对后，也会将学习到的气味表征储存数天。此外，我们发现，当小鼠在行为控制下预期结果时，整个CA1区都有稳定而稳健的信号，而当小鼠预期不可避免的厌恶结果时，则不是。这些结果显示了海马体如何编码、存储和更新学习的联想，并阐明了背侧和腹侧海马体的独特贡献。
Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue–outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor–outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus.
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