Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging.
Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging.
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DOI：
10.1039/c8nr05203d
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发表时间：
2018-10-21
期刊：
影响因子：
6.7
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Hajfathalian M ;Amirshaghaghi A ;Naha PC ;Chhour P ;Hsu JC ;Douglas K ;Dong Y ;Sehgal CM ;Tsourkas A ;Neretina S ;Cormode DP
纳米结构在传感、成像、治疗和药物输送等生物医学应用中具有潜在的应用前景。在纳米材料中，金纳米结构由于其生物惰性、表面化学可控性、X射线不透明度和光学性质而在生物医学研究中引起了极大的兴趣。金纳米笼在成像和治疗应用方面特别有吸引力，因为它们在组织中具有高透光率的近红外区强烈吸收光。然而，由于其中空结构，纳米笼的X射线衰减相对较低。在这项研究中，我们首次尝试将纳米壳层诱人的光学特性与固体纳米颗粒的高有效载荷相结合，并研究它们在生物医学中的应用。在这里，我们报道了通过将金乌尔夫形状的种子转化为金-银核−壳结构，然后进行电偶置换反应，在笼子中构建乌尔夫纳米粒子的工程。用电子显微镜测定了纳米颗粒的结构。在反应过程中，截断的八面体形状的金纳米粒子转变为笼形的复杂的Wulff纳米粒子，导致它们的光学性质发生了广泛的变化，使这些独特的结构成为潜在的光声成像造影剂。我们发现笼子中的Wulff纳米颗粒在所测试的任何浓度下对J774A.1、Renca和HepG2细胞的存活率没有不良影响。体外和体内实验显示，光声成像和计算机断层扫描都显示出强大的信号。据我们所知，这是伍尔夫在笼子里作为多种成像模式平台的第一份报告。这种独特的多功能纳米结构融合了核和壳结构的能力，使其可以用作光声成像、计算机断层扫描的造影剂，以及作为潜在的光热治疗试剂。
Nanostructures have potential for use in biomedical applications such as sensing, imaging, therapeutics, and drug delivery. Among nanomaterials, gold nanostructures are of considerable interest for biomedical research, owing to their bio-inertness, controllable surface chemistry, X-ray opacity, and optical properties. Gold nanocages are particularly attractive for imaging and therapeutic applications, because they strongly absorb light in the near infra-red region which has high light transmission in tissue. However, the X-ray attenuation of nanocages is relatively low due to their hollow structure. In this study, for the first time, we sought to combine the attractive optical properties of nanoshells with the high payloads of solid nanoparticles and investigated their biomedical applications. Here, we report the engineering of Wulff in a cage nanoparticles via converting gold Wulff-shaped seeds into gold-silver core−shell structures and then performing a galvanic replacement reaction. The structure of these nanoparticles was determined using transition electron microscopy. This morphological transformation of gold nanoparticles shaped as truncated octahedrons into a complex Wulff in a cage nanoparticles during the reaction resulted in extensive changes in their optical properties that made these unique structures a potential contrast agent for photoacoustic imaging. We found that the Wulff in a cage nanoparticles had no adverse effects on the viabilities of J774A.1, Renca, and HepG2 cells at any of the concentrations tested. In vitro and in vivo experiments showed robust signals in both photoacoustic imaging and computed tomography. To the best of our knowledge, this is the first report of Wulff in a cage nanoparticles serving as a platform for multiple imaging modalities. This unique multifunctional nanostructure, which integrates the competencies of both core and shell structures, allows their use as contrast agents for photoacoustic imaging, computed tomography and as a potential agent for photothermal therapy.
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