Host genetic susceptibility to oral cancer: evidence from meta-analyses and pooled analyses.
Host genetic susceptibility to oral cancer: evidence from meta-analyses and pooled analyses.
复制标题
宿主对口腔癌的遗传易感性：荟萃分析和汇总分析的证据。
DOI：
10.1111/odi.12184
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发表时间：
2014-10
期刊：
影响因子：
3.8
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
--
作者：
Liao, Ga;Wang, Yun;Zhou, Yuqiao;Li, Taiwen;Zeng, Dequan;Li, Jing;Dan, Hongxia;Chen, Qianming
背景
关于口腔癌遗传变异的主题，已经发表了大量的荟萃分析和汇总分析，并且已经确定了许多积极的结果;然而，可能存在一些假阳性结果。本研究的目的是使用假阳性报告概率（FPRP）方法确定“真阳性”（值得注意的）结果。
方法
检索PubMed数据库、Embase数据库、CNKI数据库和万方数据库，以检索荟萃分析、汇总分析和全基因组关联研究（GWAS），这些研究探讨了遗传多态性与口腔癌风险之间的关联。显著性相关性用FPRP方法进一步分析。
结果
从荟萃分析和汇总分析中共确定了14种变异，这些变异涉及口腔癌与遗传变异之间的关联。在这14种变异中，有9种变异与口腔癌风险显著相关（CYP 1A 1-MspI、CYP 2 E1-RsaI/PstI、MTHFR-C677 T、p73-G4 C14-to-A4 T14、XRCC 1-Arg 194 Trp、CYP 1A 1-Ile 462 Val、GSTM 1-±和NAT 2慢vs快）。在评估FPRP的结果后，9个统计学显著相关中没有一个值得注意（真阳性）。此外，GWAS未发现值得注意的结果。
结论
总之，这项研究没有发现变异与口腔癌风险之间的显著关联。因此，应进一步开展候选基因相关性研究，以探索口腔癌的病因。
BACKGROUND
A large number of meta-analyses and pooled analyses have been published on the topic of the genetic variants for oral cancer, and many positive results have been identified; however, there might be some false-positive results. The aim of this study was to identify the 'true positive' (noteworthy) results using the method of false-positive report probability (FPRP).
METHODS
The PubMed database, Embase database, CNKI database, and Wanfang database were searched to retrieve the meta-analyses, pooled analyses, and genome-wide association studies (GWAS), which addressed the associations between genetic polymorphisms and the risk of oral cancer. The significant associations were further analyzed using the method of FPRP.
RESULTS
A total of 14 variants were identified from meta-analyses and pooled analyses, which concern the associations between oral cancer and genetic variants. Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid). After assessing the results of FPRP, none of the nine statistically significant associations were noteworthy (true positive). In addition, no noteworthy results were identified from GWAS.
CONCLUSIONS
In summary, this study found no noteworthy associations between variants and the risk of oral cancer. Further candidate genes associations studies should be performed to explore the etiology of oral cancer.
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影响因子：
5
作者：
Zhi-Jiang Zhang;K. Hao;Rong Shi;Genming Zhao;G. Jiang;Yiqing Song;Xiaohui Xu;Jin Ma
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影响因子：
2.4
作者：
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作者：
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通讯作者：
Yukari Taniyama;S. Takeuchi;Y. Kuroda