Effects of very low nicotine content cigarettes on smoking across vulnerable populations.
Effects of very low nicotine content cigarettes on smoking across vulnerable populations.
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DOI：
10.1016/j.ypmed.2022.107099
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发表时间：
2022-12
影响因子：
5.1
通讯作者：
Denlinger-Apte, Rachel L.
中科院分区：
文献类型：
--
作者：
Tidey, Jennifer W.;Snell, L. Morgan;Colby, Suzanne M.;Cassidy, Rachel N.;Denlinger-Apte, Rachel L.
关键词：
长期以来，人们一直对燃烧烟草的降低尼古丁产品标准感兴趣，这属于食品和药物管理局(FDA)的监管范围。在权衡是否建立这一标准时，重要的是要考虑到与烟草相关的健康损害风险较高的人的潜在反应。在这篇叙述性综述中，我们总结了2010-2021年间对极低尼古丁含量(VLNC)香烟进行的研究，这些研究已被FDA确定为易受伤害人群。迄今为止在有精神健康问题的成年人、有阿片类药物使用障碍的成年人、处于社会经济不利地位的成年人以及年轻人中进行的研究表明，立即改用VLNC香烟可以减少吸烟，产生的意外负面后果很小或没有。很少有研究调查VLNC香烟对种族或少数民族、吸烟薄荷醇香烟的人和孕妇的影响，但初步研究结果表明，这些人的反应与在其他脆弱人群中观察到的反应相似。据我们所知，还没有研究过在军人/退伍军人、性或性别少数群体或生活在服务不足的农村环境中的人中使用VLNC香烟的研究。未来的研究方向包括了解如何在尼古丁标准降低的背景下促进戒烟，以及如何纠正脆弱人群中的VLNC误解。然而，迄今为止的证据表明，降低尼古丁标准可能会对减少吸烟产生与在较不脆弱的人群中相同的有益影响，这应该会为采取这种监管方法提供一些信心。
There has been long-standing interest in a reduced-nicotine product standard for combusted tobacco, which is within the regulatory purview of the Food and Drug Administration (FDA). In weighing whether to establish this standard, it is important to consider potential responses among people who are at elevated risk for tobacco-related health harms. In this narrative review, we summarize studies of very low nicotine content (VLNC) cigarettes conducted between 2010–2021 in groups that the FDA has identified as vulnerable populations. Studies conducted to date in adults with mental health conditions, adults with opioid use disorder, socioeconomically-disadvantaged adults, and youth or young adults indicate that immediate switching to VLNC cigarettes decreases smoking, with minimal or no unintended negative consequences. Few studies have investigated the effects of VLNC cigarettes in racial or ethnic minorities, people who smoke menthol cigarettes, and pregnant women, but initial findings suggest that responses of these individuals are similar to responses observed in other vulnerable populations. We are not aware of studies that have investigated VLNC cigarettes in military/veteran populations, sexual or gender minority individuals, or people living in underserved rural environments. Future research directions include understanding how to promote cessation in the context of a reduced-nicotine standard, and how to correct VLNC misperceptions in vulnerable populations. Nevertheless, the evidence to date indicates that a reduced-nicotine standard is likely to have the same beneficial effects on smoking reductions as it does in less vulnerable populations, which should provide some confidence in pursuing this regulatory approach.
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影响因子：
3.4
作者：
Sweitzer MM;Pacek LR;Kozink RV;Locey E;Kollins SH;Donny EC;McClernon FJ
通讯作者：
McClernon FJ
DOI：
10.3390/ijerph18105311
发表时间：
2021-05-17
影响因子：
--
作者：
Denlinger-Apte RL;Pacek LR;Ross JC;Bansal-Travers M;Donny EC;Hatsukami DK;Carroll DM
通讯作者：
Carroll DM
DOI：
10.1158/1055-9965.epi-11-0644
发表时间：
2012-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Benowitz NL;Dains KM;Hall SM;Stewart S;Wilson M;Dempsey D;Jacob P 3rd
通讯作者：
Jacob P 3rd
影响因子：
4.2
作者：
Carroll DM;Lindgren BR;Dermody SS;Denlinger-Apte R;Egbert A;Cassidy RN;Smith TT;Pacek LR;Allen AM;Tidey JW;Parks MJ;Koopmeiners JS;Donny EC;Hatsukami DK
通讯作者：
Hatsukami DK
影响因子：
4.2
作者：
Cassidy, Rachel N.;Colby, Suzanne M.;Hatsukami, Dorothy
通讯作者：
Hatsukami, Dorothy