Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. Military aviation facilities.
Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. Military aviation facilities.
复制标题
DOI：
10.1289/ehp.6592
复制
发表时间：
2004-05
影响因子：
10.4
通讯作者：
Smith AH
中科院分区：
文献类型：
--
作者：
Steinmaus C;Lu M;Todd RL;Smith AH
最近，内华达州丘吉尔县法伦市周围发生了一系列独特的儿童白血病。从1999年到2001年，这个县有23,982人被诊断出11例病例。与附近海军航空站有关的暴露，如喷气燃料或海军飞行员携带的传染性病原体，被假设为潜在原因。还考虑了集群可能归因于偶然的可能性。我们使用了来自监测、流行病学和最终结果计划（SEER）的数据来检查机会可以解释这一集群的可能性。我们还使用SEER和加州癌症登记处的数据来评估美国其他拥有军事航空设施的县的儿童白血病发病率。丘吉尔县的年龄标准化率比（RR）为12.0 [95%置信区间（CI），6.0-21.4; p = 4.3乘以符号10（-9）]。这种规模的集群预计每22，000年在美国偶然发生一次。在首次报告该集群后诊断的5例病例的年龄标准化RR为11.2（95%CI，3.6-26.3）。相比之下，在美国所有其他拥有军事航空基地的县（RR = 1.04; 95%CI，0.97-1.12）或拥有军事航空基地的农村县子集（RR = 0.72; 95%CI，0.48-1.08）中，发病率没有增加。这些发现表明，丘吉尔县的聚集性不太可能是偶然的，但在美国其他有军事航空基地的县中，儿童白血病的普遍增加并没有被发现。
A unique cluster of childhood leukemia has recently occurred around the city of Fallon in Churchill County, Nevada. From 1999 to 2001, 11 cases were diagnosed in this county of 23,982 people. Exposures related to a nearby naval air station such as jet fuel or an infectious agent carried by naval aviators have been hypothesized as potential causes. The possibility that the cluster could be attributed to chance was also considered. We used data from the Surveillance, Epidemiology, and End Results Program (SEER) to examine the likelihood that chance could explain this cluster. We also used SEER and California Cancer Registry data to evaluate rates of childhood leukemia in other U.S. counties with military aviation facilities. The age-standardized rate ratio (RR) in Churchill County was 12.0 [95% confidence interval (CI), 6.0-21.4; p = 4.3 times symbol 10(-9)]. A cluster of this magnitude would be expected to occur in the United States by chance about once every 22,000 years. The age-standardized RR for the five cases diagnosed after the cluster was first reported was 11.2 (95% CI, 3.6-26.3). In contrast, the incidence rate was not increased in all other U.S. counties with military aviation bases (RR = 1.04; 95% CI, 0.97-1.12) or in the subset of rural counties with military aviation bases (RR = 0.72; 95% CI, 0.48-1.08). These findings suggest that the Churchill County cluster was unlikely due to chance, but no general increase in childhood leukemia was found in other U.S. counties with military aviation bases.
登录
查看更多内容
影响因子：
105.7
作者：
KINLEN, LJ;DICKSON, M;STILLER, CA
通讯作者：
STILLER, CA
影响因子：
1.9
作者：
Harris, DT;Sakiestewa, D;Witten, M
通讯作者：
Witten, M
影响因子：
5.9
作者：
HEATH, CW;HASTERLIK, RJ
通讯作者：
HASTERLIK, RJ
影响因子：
--
作者：
KINLEN, LJ;OBRIEN, F;MATTHEWS, F
通讯作者：
MATTHEWS, F
影响因子：
1.9
作者：
Harris, DT;Sakiestewa, D;Witten, M
通讯作者：
Witten, M