The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction.
The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction.
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DOI：
10.1016/j.neuropharm.2013.06.013
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发表时间：
2014-01
影响因子：
4.7
通讯作者：
Wilson AG
中科院分区：
文献类型：
--
作者：
Bickel WK;Koffarnus MN;Moody L;Wilson AG
成瘾科学将受益于行为标记的识别。行为标记物可以反映疾病的预计临床过程，用作临床结果的替代测量，和/或可以与疾病的生物成分相关。在本文中，我们回顾了相关文献，可能与早期和持续的支持NIDA，以确定是否时间折扣，神经行为过程来自行为经济学，并通过神经经济学进一步探讨，可以作为一个行为标记。我们的综述表明，时间折扣1）识别药物依赖的个体，2）识别那些有发展药物依赖风险的人，3）作为成瘾严重程度的衡量标准，4）与成瘾发展的所有阶段相关，5）有效治疗的变化，以及6）可能与成瘾的生物和遗传过程有关。因此，初步证据支持时间折扣作为候选行为标记。需要在几个领域进行更多的研究，才能得出更明确的结论。确认时间折扣功能作为成瘾的行为标志物可能导致1）筛选新的治疗方法，2）预防和治疗干预的个性化，以及3）将时间折扣作为其他病因相似的疾病的行为标志物。
Addiction science would benefit from the identification of a behavioral marker. A behavioral marker could reflect the projected clinical course of the disorder, function as a surrogate measure of clinical outcome, and/or may be related to biological components that underlie the disorder. In this paper we review relevant literature, made possible with the early and sustained support by NIDA, to determine whether temporal discounting, a neurobehavioral process derived from behavioral economics and further explored through neuroeconomics, may function as a behavioral marker. Our review suggests that temporal discounting 1) identifies individuals who are drug-dependent, 2) identifies those at risk of developing drug dependence, 3) acts as a gauge of addiction severity, 4) correlates with all stages of addiction development, 5) changes with effective treatment, and 6) may be related to the biological and genetic processes that underlie addiction. Thus, initial evidence supports temporal discounting as a candidate behavioral marker. Additional studies will be required in several areas for a more conclusive determination. Confirmation that temporal discounting functions as a behavioral marker for addiction could lead to 1) a screen for new treatments, 2) personalization of prevention and treatment interventions, and 3) the extension of temporal discounting as a behavioral marker for other etiologically similar disorders.
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影响因子：
3.4
作者：
Bickel, Warren K.;Landes, Reid D.;Christensen, Darren R.;Jackson, Lisa;Jones, Bryan A.;Kurth-Nelson, Zeb;Redish, A. David
通讯作者：
Redish, A. David
影响因子：
4.4
作者：
Audrain-McGovern, Janet;Rodriguez, Daniel;Epstein, Leonard H.;Rodgers, Kelli;Cuevas, Jocelyn;Wileyto, E. Paul
通讯作者：
Wileyto, E. Paul
影响因子：
13.5
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Koffarnus, Mikhail N.;Gatchalian, Kirstin M.
通讯作者：
Gatchalian, Kirstin M.
影响因子：
3.4
作者：
Amlung M;Sweet LH;Acker J;Brown CL;MacKillop J
通讯作者：
MacKillop J
影响因子：
3.4
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Gatchalian, Kirstin M.;McClure, Samuel M.
通讯作者：
McClure, Samuel M.